227310-27-2Relevant academic research and scientific papers
Photoactive platinum(II) β-diketonates as dual action anticancer agents
Raza, Md Kausar,Mitra, Koushambi,Shettar, Abhijith,Basu, Uttara,Kondaiah, Paturu,Chakravarty, Akhil R.
, p. 13234 - 13243 (2016)
Platinum(ii) complexes, viz. [Pt(L)(cur)] (1), [Pt(L)(py-acac)] (2) and [Pt(L)(an-acac)] (3), where HL is 4,4′-bis-dimethoxyazobenzene, Hcur is curcumin, Hpy-acac and Han-acac are pyrenyl and anthracenyl appended acetylacetone, were prepared, characterized and their anticancer activities were studied. Complex [Pt(L)(acac)] (4) was used as a control. Complex 1 showed an absorption band at 430 nm (? = 8.8 × 104 M-1 cm-1). The anthracenyl and pyrenyl complexes displayed bands near 390 nm (? = 3.7 × 104 for 3 and 4.4 × 104 M-1 cm-1 for 2). Complex 1 showed an emission band at 525 nm (Φ = 0.017) in 10% DMSO-DPBS (pH, 7.2), while 2 and 3 were blue emissive (λem = 440 and 435, Φ = 0.058 and 0.045). There was an enhancement in emission intensity on glutathione (GSH) addition indicating diketonate release. The platinum(ii) species thus formed acted as a transcription inhibitor. The released β-diketonate base showed photo-chemotherapeutic activity. The complexes photocleaved plasmid DNA under blue light of 457 nm forming ～75% nicked circular (NC) DNA with hydroxyl radicals and singlet oxygen as the ROS. Complexes 1-3 were photocytotoxic in skin keratinocyte HaCaT cells giving IC50 of 8-14 μM under visible light (400-700 nm, 10 J cm-2), while being non-toxic in the dark (IC50: ～60 μM). Complex 4 was inactive. Complexes 1-3 generating cellular ROS caused apoptotic cell death under visible light as evidenced from DCFDA and annexin-V/FITC-PI assays. This work presents a novel way to deliver an active platinum(ii) species and a phototoxic β-diketone species to the cancer cells.
Oxidative addition to cyclometalated azobenzene platinum(II) complexes: A route to octahedral liquid crystalline materials
Ghedini, Mauro,Pucci, Daniela,Crispini, Alessandra,Barberio, Giovanna
, p. 2116 - 2124 (2008/10/08)
The 4,4′-disubstituted azobenzene ligands HLa-d react with [(η3-C4H7)Pt(μ-Cl)]2 to give the dinuclear cycloplatinated complexes [(La-d)Pt(μ-Cl)]2, which are easily converted to t
