227315-20-0

Basic information

• Product Name: N,N'-bis-[(S)-1'-phenylethyl]-(1R,2R,4R,5S)-1,2-diamino-4,5-dimethyl-cyclohexane
• Synonyms: N,N'-bis-[(S)-1'-phenylethyl]-(1R,2R,4R,5S)-1,2-diamino-4,5-dimethyl-cyclohexane
• CAS NO: 227315-20-0
• Molecular Weight: 350.547
• Mol File: 227315-20-0.mol

Chemical Properties

• CAS DataBase Reference: N,N'-bis-[(S)-1'-phenylethyl]-(1R,2R,4R,5S)-1,2-diamino-4,5-dimethyl-cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-bis-[(S)-1'-phenylethyl]-(1R,2R,4R,5S)-1,2-diamino-4,5-dimethyl-cyclohexane(227315-20-0)
• EPA Substance Registry System: N,N'-bis-[(S)-1'-phenylethyl]-(1R,2R,4R,5S)-1,2-diamino-4,5-dimethyl-cyclohexane(227315-20-0)

Safety Data

• Hazardous Substances Data: 227315-20-0(Hazardous Substances Data)

Upstream product

• 138812-19-8 (4R,5R)-N₄,N₅-bis((S)-1-phenylethyl)octa-1,7-diene-4,5-diamine 
• 138812-17-6 N,N'-bis<(S)-1-phenylethyl>ethanediimine 

Relevant articles and documents

Influence of the metal and chiral diamine on metal(II)salen catalysed, asymmetric synthesis of α-methyl α-amino acids

The influence of the metal ion and chiral diamine used to form a metal(salen) complex on the catalytic activity of the complex in the asymmetric benzylation of an alanine enolate was investigated. Only metal ions which could form square-planar complexes g

Asymmetric Synthesis of 1,2-Diamino-4,5-dimethylcyclohexanes by Zirconium-Catalyzed and -Promoted Reductive Cyclization Reactions

The asymmetric synthesis of 1,2-diamino-4,5-dimethylcyclohexanes was achieved by the zirconium-catalyzed and -promoted reductive cyclization of N,N′-di[(S)-1-phenylethyl]-4CR),5(R)-diamino-1,7-octadiene. The reaction of the diene with 5 equiv of butylmagnesium chloride and 0.1 mol % of bis(cyclopentadienyl)zirconium dichloride in diethyl ether at 0-20°C gave mainly the 1(R),2(R)-diamino-4(S),5(S)-dimethylcyclohexane derivative having C2 symmetry, but the reaction with 4 equiv of dibutylzirconocene in tetrahydrofuran at -78 to -50°C gave prevalently the diastereomer with the 4(R),5(S) configuration. By reductive cleavage of the auxiliary, followed by sulfonylation reaction, 1(R),2(R)-di(4-toluenesulfonyl)amino)-4(S),5(S)-dimethylcyclohexane was prepared.