227319-36-0

Basic information

• Product Name: methyl 3-amino-3-(4-methoxyphenyl)propanoate
• Synonyms: methyl 3-amino-3-(4-methoxyphenyl)propanoate
• CAS NO: 227319-36-0
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.2417
• Mol File: 227319-36-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 3-amino-3-(4-methoxyphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-3-(4-methoxyphenyl)propanoate(227319-36-0)
• EPA Substance Registry System: methyl 3-amino-3-(4-methoxyphenyl)propanoate(227319-36-0)

Safety Data

• Hazardous Substances Data: 227319-36-0(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 131791-82-7 3-amino-3-(4-methoxyphenyl)propionic acid methyl ester 
• 309977-86-4 (R)-methyl 3-(tert-butoxycarbonyl)-3-(4-methoxyphenyl)propanoate 
• 79-20-9 acetic acid methyl ester 
• 67-56-1 methanol 
• 131690-56-7 (S)-β-amino-β-(4-methoxyphenyl)propionic acid 
• 5678-45-5 3-amino-3-(4-methoxyphenyl)propionic acid 
• 22027-50-5 methyl 3-(4-methoxybenzoyl)acetate 
• 329013-12-9 (S)-N-tert-butyloxycarbonyl β-Tyr 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1271792-72-3 (R,Z)-methyl 3-(4-methoxyphenyl)-3-(1-phenylethylamino)acrylate 
• 131791-83-8 (S)-2-tert-Butyl-6-(4-methoxyphenyl)-5,6-dihydro-4-(1H)-pyrimidinone 
• 96363-21-2 methyl (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionate 
• 159848-74-5 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate 

Downstream Products

• 159848-76-7 methyl (+)-(3S)-3-amino-3-(4-methoxyphenyl)propanoate 
• 131791-82-7 methyl (-)-(3R)-3-amino-3-(4-methoxyphenyl)propanoate 
• 1218781-43-1 C₂₂H₃₄N₂O₆ 
• 1218781-44-2 C₁₇H₂₆N₂O₄ 
• 1218781-47-5 C₃₃H₅₃N₅O₆ 
• 96363-21-2 methyl D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)propanoate 
• 1243990-40-0 C₃₀H₃₉N₃O₇ 

Relevant articles and documents

Catalytic asymmetric oxidative carbonylation-induced kinetic resolution of sterically hindered benzylamines to chiral isoindolinones

A highly enantioselective kinetic resolution of sterically hindered benzylamines has been achieved for the first time through transition-metal-catalyzed oxidative carbonylation, in which the new KR strategy offered a new approach to afford chiral isoindolinones (er up to 97?:?3) and the origin of chemoselectivity and stereoselectivity was confirmed by density functional theory (DFT) calculations.

Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity

Eight sansalvamide A peptide analogues with 4′-fluoride, 4′-chloride, 4′-bromide, 4′-iodide, and 4′- methoxyphenylalanine moieties were synthesized. The effect of these para-substitutions of sansalvamide A peptide on their cytotoxicity was evaluated using HCT-116, MDA-MB-231, HT-29, HCT-15, K562, HeLa, and A549 cell lines. The 4′-methoxyphenylalanine analog of sansalvamide A peptide was found to be a promising antitumor agent.

Practical, catalytic enantioselective hydrogenation to synthesize N -unprotected β-amino esters

Practical and simple catalytic enantioselective hydrogenation reactions to synthesize N-unprotected β-amino esters have been developed: (1) asymmetric hydrogenation of N-unprotected β-enamine ester and (2) asymmetric direct reductive amination of β-keto esters using ammonium salts. A Ru-DM-SEGPHOS complex was used as the catalyst in both cases and gave high enantioselectivity, high reactivity, and wide substrate applicability. These protocols greatly reduced reaction time and waste compared to conventional synthetic routes. The direct reductive amination route was demonstrated on a >100 kg scale.