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5-Pyrimidinecarboxylic acid, 2-chloro-4-[[3-(trifluoromethyl)phenyl]amino]- is a complex organic compound with the chemical formula C12H7ClF3N3O2. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound consisting of a six-membered ring, with four carbon atoms and two nitrogen atoms. This specific compound features a 2-chloro-4-[[3-(trifluoromethyl)phenyl]amino] substituent attached to the pyrimidine core, which introduces a chlorine atom, a trifluoromethyl group, and an amino group connected to a phenyl ring. The presence of these functional groups endows the molecule with unique chemical properties and potential applications in various fields, such as pharmaceuticals and agrochemicals, where it may act as an intermediate in the synthesis of more complex molecules.

227449-28-7

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227449-28-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 227449-28-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,7,4,4 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 227449-28:
(8*2)+(7*2)+(6*7)+(5*4)+(4*4)+(3*9)+(2*2)+(1*8)=147
147 % 10 = 7
So 227449-28-7 is a valid CAS Registry Number.

227449-28-7Relevant academic research and scientific papers

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives

Hisamichi, Hiroyuki,Naito, Ryo,Toyoshima, Akira,Kawano, Noriyuki,Ichikawa, Atsushi,Orita, Akiko,Orita, Masaya,Hamada, Noritaka,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi

, p. 4936 - 4951 (2007/10/03)

Spleen tyrosine kinase (Syk) is a non-receptor-type tyrosine kinase which mediates diverse responses in haematopoietic cells. Therefore, Syk is an attractive therapeutic target, and in a study of Syk inhibitors as potentially new therapeutic agents, we di

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