227458-61-9Relevant academic research and scientific papers
Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of D-gluco- and D-xylopyranosylidene-spiro-(thio)hydantoins and N-(D-glucopyranosyl) amides
Somsák,Kovács,Tóth,?sz,Szilágyi,Gy?rgydeák,Dinya,Docsa,Tóth,Gergely
, p. 2843 - 2848 (2007/10/03)
D-Gluco- and D-xylopyranosylidene-spiro-hydantoins and -thiohydantoins were prepared from the parent sugars in a six-step, highly chemo-, regio-, and stereoselective procedure. In the key step of the syntheses C-(1-bromo-1-deoxy-β-D-glycopyranosyl)formami
Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin
Osz, Erzsebet,Somsak, Laszlo,Szilagyi, Laszlo,Kovacs, Laszlo,Docsa, Tibor,Toth, Bela,Gergely, Pal
, p. 1385 - 1390 (2007/10/03)
Reaction of C-(1-bromo-1-deoxy-β-D-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D- glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.
