227595-84-8Relevant academic research and scientific papers
Synthesis and biological evaluation of novel Bis[1,2,4]triazolo[3,4-b] [1,3,4]oxadiazoles
Sanjeeva Reddy,Vani Devi,Rajesh Kumar,Sunitha,Nagaraj
, p. 557 - 562 (2013)
A series of novel 6-2-methoxy-5-[4-methoxy-3-(3-aryl[1,2,4]triazolo[3,4-b] [1,3,4]oxadiazol-6-yl)benzyl]phenyl-3-aryl[1,2,4]triazolo[3,4-b][1,3,4] oxadiazoles 7a-j has been synthesized and characterized via IR, 1H NMR, 13C NMR, MS, and elemental analyses. Compounds 7a-j were also screened for their antibacterial activity against Gram-positive bacteria viz. Bacillus subtilis (MTCC 441), Bacillus sphaericus (MTCC 11), and Staphylococcus aureus (MTCC 96), and Gram-negative bacteria viz. Pseudomonas aeruginosa (MTCC 741), Klobsinella aerogenes (MTCC 39), and Chromobacterium violaceum (MTCC 2656). The antibacterial screening reveal that the presence of 2,4-difluorophenyl (7e) or 4-nitrophenyl (7f) of 2-pyrazyl (7i), or 2-furyl (7j) on the triazole moiety exhibited potent inhibitory activity comparable with the standard drug streptomycin, at the tested concentrations, and emerged as potential molecules for further development.
Synthesis of novel bis-(1,3,4-oxadiazol-2-ylamino)-2-aryl-1,3 -thiazolan-4-ones as antimicrobial, nematicidal and anticancer agents
Kumar, Gaddam Rajesh,Shankar, Kurre,Reddy, Cherkupally Sanjeeva
, p. 700 - 714 (2019/05/22)
A series of novel bis-heterocycles, 3-(5-[2-methoxy-5-(4-methoxy-3-5-[(4-oxo-2-(aryl/hetaryl) -1,3-thiazolan -3- yl)animo]-l,3,4-oxadiazol-2-ylberizyl)phenyl]-l,3,4-oxadazol-2-ylamimo)-2-(aryl/lietaryl)-l,3-thizolan-4-ones 8a-j have been synthesized by simple and high yield routes. Structures of all the newly synthesized compounds have been established by their spectral data and elemental analysis, and they have been evaluated for their in vitro antimicrobial, nematicidal and anticancer activities. Among the tested compounds, those with 4-chlorophenyl (8c), 3-nitrophenyl (8d) and 2,4- difluorophenyl (8f) substituents at 2-position of thiazolidinone ring are found to be potent antibacterial and antifungal agents. Exploration of nematicidal activity of compounds 8a-j reveal that, compounds 8f, 8i and 8j bearing 2,4- difluorophenyl, 2-furyl and 1,3-benzodioxole substituents respectively at 2nd position of thiazolidinone ring show prominent activity comparable to the standard levamisole and have emerged as potential nematicidal agents. In vitro anticancer activity assay reveals that the compounds with electron-withdrawing groups viz., 4-chlorophenyl (8c), 3-nitrophenyl (8d) and 2,4- difluorophenyl (8f) display significant activity which is more than the standard against A549 (lung cancer) cell line, and compounds bearing electron-donating groups such as 4-methylphenyl (8b), 4-hydroxyphenyl (8e), N,N- dimethylaminophenyl (8g), and 4-methoxy-3-hydroxyphenyl (8h) show superior/comparable potency to the standard against MDAMB-231 (breast cancer) cell line. The docking scores estimated by Schr?dinger software also correlate well with the experimental anticancer activity.
Synthesis and antimicrobial activity of bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl) phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl) phenyl]methanes
Srinivas, Avula
, p. 173 - 179 (2016/03/19)
A series of novel bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes (5a-e and 6a-e) has been synthesized and characterized by IR, 1H and 13C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d, 5e, 6b, 6c and 6e exhibited potent activity against the tested bacteria and fungi, and emerged as potential molecules for further development.
Synthesis and evaluation of novel bis[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles as potent antimicrobial agents
Reddy, Cherkupally Sanjeeva,Rao, Lade Sanjeeva,Nagaraj, Adki
experimental part, p. 726 - 732 (2010/12/19)
A series of novel bis[4-methoxy-3-(6-aryl[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol)phenyl]methanes 5a-l has been synthesized and characterized via IR,1H NMR,13C NMR, MS and elemental analyses. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Bacillus sphaericu, Staphylococcus aureus, Pseudomonas aeruginosa, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5e, 5f, 5h, 5i, 5k and 5l exhibited potent activity against the test bacteria and fungi, and emerged as potential molecules for further development.
