227616-01-5

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 19460-86-7 (N-methyl)-L-phenylalanine methyl ester hydrochloride 
• 2439-60-3 N-methyl-L-phenylalanine methyl ester 

Downstream Products

• 438241-39-5 2-[(2-{2-[2-(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-octanoylamino)-propionyloxy]-4-cyano-butyrylamino}-4-methyl-octanoyl)-methyl-amino]-4-methyl-pentanoic acid tert-butyl ester 
• 438241-35-1 2-{[2-(2-{[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-octanoyl)-methyl-amino]-acetoxy}-4-cyano-butyrylamino)-4-methyl-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester 
• 438241-25-9 2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester 
• 438241-31-7 (S)-2-{[(S)-2-((R)-2-{2-[((S)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-acetoxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester 
• 438241-37-3 (S)-2-((2S,4R)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-octanoylamino)-propionic acid methyl ester 
• 438240-69-8 (S)-2-[((2S,4R)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-octanoyl)-methyl-amino]-propionic acid methyl ester 
• 438241-33-9 [((2S,4R)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-4-methyl-octanoyl)-methyl-amino]-acetic acid methyl ester 
• 438241-23-7 (S)-2-[((S)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionic acid methyl ester 
• 438241-29-3 [((S)-2-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-acetic acid methyl ester 
• 909108-78-7 (S)-2-{[(S)-2-((S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoyl]-methyl-amino}-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

N4-methylation changes the conformation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones from folded to extended

N4-methylation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones (S,S)-1a-c was found to change their folded conformation to an extended conformation. Conformational aspects of N1- and/or N4-methylated (S,S)-1a-c were revealed by single crystal X-ray crystallography and 1H NMR spectroscopy.

Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines

We report an extensive structure-activity relationship (SAR) of 62 compounds active against two drug-resistant colon cancer cell lines. Our comprehensive evaluation of two generations of compounds utilizes SAR, NMR, and molecular modeling to evaluate the

Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29

We report the synthesis of thirty-six Sansalvamide A derivatives, and their biological activity against colon cancer HT-29 cell line, a microsatellite stable (MSS) colon cancer cell-line. The thirty-six compounds can be divided into three subsets, where t

Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: A general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides

HUN-7293 (1), a naturally occurring cyclic heptadepsipeptide, is a potent inhibitor of cell adhesion molecule expression (VCAM-1, ICAM-1, E-selectin), the overexpression of which is characteristic of chronic inflammatory diseases. Representative of a gene