227616-53-7Relevant academic research and scientific papers
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structre-activity studies
Dragovich, Peter S.,Webber, Stephen E.,Babine, Robert E.,Fuhrman, Shella A.,Patick, Amy K.,Matthews, David A.,Lee, Caroline A.,Reich, Siegfried H.,Prins, Thomas J.,Marakovits, Joseph T.,Littlefield, Ethel S.,Zhou, Ru,Tikhe, Jayashree,Ford, Clifford E.,Wallace, Michael B.,Meador III, James W.,Ferre, Rose Ann,Brown, Edward L.,Binford, Susan L.,Harr, James E. V.,DeLisle, Dorothy M.,Worland, Stephen T.
, p. 2806 - 2818 (2007/10/03)
The structure-based design, chemical synthesis, and biological evaluation of peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds incorporate various Michael acceptor moieties and are shown to irreversibly bin
