227616-82-2Relevant academic research and scientific papers
Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier
Fan, Xing,Zhang, Hu-Shan,Chen, Li,Long, Ya-Qiu
experimental part, p. 2827 - 2840 (2010/08/22)
By employing pharmacophore-based design and the privileged fragments reassembly, a series of piperidine-/tropane-/piperazine-bridged CCR5 antagonists were designed and synthesized via an efficient convergent synthesis strategy, with focus on the optimal choice of the basic center carrier structure. Significantly, the 4-amino-4-methylpiperidine bridged 1-acyl-1,3-propanediamine compounds were identified as a new class of nanomolar CCR5 antagonists, providing an efficient approach and novel scaffolds for further development of potent CCR5 inhibitors.
Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements
Coleman, Paul J,Brashear, Karen M,Hunt, Cecilia A,Hoffman, William F,Hutchinson, John H,Breslin, Michael J,McVean, Carol A,Askew, Ben C,Hartman, George D,Rodan, Sevgi B,Rodan, Gideon A,Leu, Chih-Tai,Prueksaritanont, Thomayant,Fernandez-Metzler, Carmen,Ma, Bennett,Libby, Laura A,Merkle, Kara M,Stump, Gary L,Wallace, Audrey A,Lynch, Joseph J,Lynch, Robert,Duggan, Mark E
, p. 31 - 34 (2007/10/03)
Potent non-peptidic αvβ3 antagonists have been prepared incorporating various β-amino acids as aspartic acid mimetics. Modification of the β-alanine 3-substituents alters the potency and physicochemical properties of these receptor a
