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ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

    Cas No: 227617-15-4

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  • 227617-15-4 Structure
  • Basic information

    1. Product Name: ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate
    2. Synonyms: ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate
    3. CAS NO:227617-15-4
    4. Molecular Formula: C17H17N3O4
    5. Molecular Weight: 327.33458
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 227617-15-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 493.4±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.32±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.08±0.50(Predicted)
    10. CAS DataBase Reference: ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate(227617-15-4)
    12. EPA Substance Registry System: ethyl 4-hydroxy-1-(4-Methoxybenzyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxylate(227617-15-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 227617-15-4(Hazardous Substances Data)

227617-15-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 227617-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,7,6,1 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 227617-15:
(8*2)+(7*2)+(6*7)+(5*6)+(4*1)+(3*7)+(2*1)+(1*5)=134
134 % 10 = 4
So 227617-15-4 is a valid CAS Registry Number.

227617-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

1.2 Other means of identification

Product number -
Other names ethyl 4-hydroxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:227617-15-4 SDS

227617-15-4Relevant articles and documents

Growth Factor Receptor antagonists. Preparation method and application thereof

-

Paragraph 0133-0134; 0143-0146, (2021/11/27)

The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.

INHIBITORS OF BRUTON'S TYROSINE KINASE

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Page/Page column 109, (2018/06/06)

The present invention relates to a new compound of formula I: or pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: V1 is C or N, V2 is C(R2) or N, whereby if V1 is C then V2 is N, if V1 is C then V2 is C(R2), or if V1 is N then V2 is C(R2); each n, k is independently 0, 1; each R2, R11 is independently H, D, Hal, CN, NR'R", C(O)NR'R", C1-C6 alkoxy; R3 is H, D, hydroxy, C(O)C1-C6 alkyl, C(O)C2-C6 alkenyl, C(O)C2-C6 alkynyl, C1-C6 alkyl; R4 is H, Hal, CN, CONR'R", hydroxy, C1-C6 alkyl, C1-C6 alkoxy; L is CH2, NH, O or chemical bond; R1 is selected from the group of the fragments, comprising: Fragment 1, Fragment 2, Fragment 3 each A1, A2, A3, A4 is independently CH, N, CHal; each A5, A6, A7, A8, A9 is independently C, CH or N; R5 is H, CN, Hal, CONR'R", C1-C6 alkyl, non-substituted or substituted by one or more halogens; each R' and R" is independently selected from the group, comprising H, C1-C6 alkyl, C1-C6 cycloalkyl, aryl; R6 is selected from the group: [formula II] each R7, R8, R9, R10 is independently vinyl, methylacetylenyl; Hal is CI, Br, I, F, which have properties of inhibitor of Bruton's tyrosine kinase (Btk), to pharmaceutical compositions containing such compounds, and their use as pharmaceuticals for treatment of diseases and disorder.

THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

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Paragraph 0804; 0805, (2014/07/23)

The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

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Page/Page column 132, (2013/09/12)

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

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Page/Page column 83; 84, (2013/09/12)

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES

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Page/Page column 145, (2013/09/12)

Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Zheng, Xiaozhang,Bair, Kenneth W.,Bauer, Paul,Baumeister, Timm,Bowman, Krista K.,Buckmelter, Alexandre J.,Caligiuri, Maureen,Clodfelter, Karl H.,Feng, Yezhen,Han, Bingsong,Ho, Yen-Ching,Kley, Nikolai,Li, Hong,Liang, Xiaorong,Liederer, Bianca M.,Lin, Jian,Ly, Justin,O'Brien, Thomas,Oeh, Jason,Oh, Angela,Reynolds, Dominic J.,Sampath, Deepak,Sharma, Geeta,Skelton, Nicholas,Smith, Chase C.,Tremayne, Jarrod,Wang, Leslie,Wang, Weiru,Wang, Zhongguo,Wu, Hongxing,Wu, Jiansheng,Xiao, Yang,Yang, Guangxing,Yuen, Po-Wai,Zak, Mark,Dragovich, Peter S.

supporting information, p. 5488 - 5497 (2013/10/01)

Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using structure-based design techniques. Many of these compounds exhibited nanomolar antiproliferation activities a

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

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Page/Page column 61; 62, (2013/09/12)

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.

AMIDO-BENZYL SULFOXIDE DERIVATIVES

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Paragraph 0179, (2013/09/12)

The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat

ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES

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Paragraph 0187, (2013/09/12)

The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,

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