227754-45-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 227754-42-9 2'-O-tetrahydropyranyl-5-bromouridine 
• 957-75-5 5-bromouridine 
• 102789-25-3 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-5-bromouridine 

Downstream Products

• 227754-48-5 5'-O-dimethoxytrityl-2'-O-tetrahydropyranyl-5-bromouridine 3'-H-phosphonate 

Relevant academic research and scientific papers

H-phosphonate synthesis of oligoribonucleotides containing modified bases. I. Photoactivatable derivatives of oligoribonucleotides with perfluoroarylazide groups in heterocyclic bases

H-phosphonate synthesis was proposed for oligoribonucleotides containing a bromine atom or an ethylenediamine linker at positions C5 or C8 of uridine or adenosine, respectively. Novel photoactivatable derivatives of oligoribonucleotides harboring a p-azidotetrafluorobenzoyl group attached to uridine or adenosine through the diamino linker were synthesized.

The H-phosphonate synthesis of oligoribonucleotides containing modified bases

An alternative solid phase H-phosphonate synthesis of oligoribonucleotides bearing a bromine atom or an aliphatic amino linker at position C-5 of uridine or C-8 of adenosine was proposed.