22776-74-5

Usage

InChI:InChI=1/C10H17N/c1-7-2-9-3-8(1)5-10(4-7)11-6-9/h7-11H,1-6H2

Upstream product

• 22607-75-6 4-azatricyclo<4.3.1.1.^3,8>undecan-5-one 
• 65218-91-9 4-azatricyclo[4.3.1.1(3,8)]undec-4-ene 

Downstream Products

• 102197-24-0 4-(3'-phenylpropen-2'-yl)-4-azatricyclo<4.3.1.1^3,8>undecane hydrochloride 
• 147055-15-0 4-phenyl-3-oxa-2-azatetracyclo<7.3.1.1^7,11.0^2,6>tetradec-4-ene 
• 147055-13-8 5-phenacylidene-4-azahomoadamantane 
• 102197-30-8 4-(p-methoxycinnamoyl)-4-azatricyclo<4.3.1.1^3,8>undecane 
• 102197-31-9 4-(p-nitrocinnamoyl)-4-azatricyclo<4.3.1.1^3,8>undecane 
• 102197-29-5 4-(m-nitrobenzoyl)-4-azatricyclo<4.3.1.1^3,8>undecane 
• 102197-22-8 4-(p-nitrobenzoyl)-4-azatricyclo<4.3.1.1^3,8>undecane 
• 102197-32-0 4-<(m-trifluoromethyl)cinnamoyl>-4-azatricyclo<4.3.1.1^3,8>undecane 
• 24280-74-8 4-azatricyclo[4.3.1.13.8 ] undecane hydrochloride 

Relevant academic research and scientific papers

SYNTHESIS OF 4-AZAHOMOADAMANT-4-ENE N-OXIDES AND THEIR 1,3-DIPOLAR CYCLOADDITION REACTIVITY

Nitrones incorporated in a homoadamantane ring system, which were obtained by SeO2-H2O2 oxidation of 4-azahomoadamantane, underwent 1,3-dipolar cycloaddition reaction with electron-deficient alkynes (not with alkenes) to give 4-substituted isoxazoline spe

CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM

In alternative embodiments, the invention provides nucleophilic hydroxyimino- acetamido alkylamine antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). The hydroxyimino-acetamido alkylamines of the invention are designed to fit within AChE active center gorge dimensions, bind with reasonable affinity, and react with the conjugated phosphate atom in the gorge. The hydroxyimino- acetamido alkylamines of the invention are also designed to possess ionization states that govern affinity and reactivity for the two linked hAChE re-activation steps. In alternative embodiments, the invention provides pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi- chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound of the invention.

HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS

Described are bridged compounds of the formula (I), their analogs, tautomeric forms, stereoisomers, geometrical isomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The invention relates to compositions and methods to treat fungal infection. These compounds are selective HDAC inhibitors that act as inherent antifungal compounds or enhance the activity of other antifungal compounds such as azoles.

ADAMANTANE ANALOGS

Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

Guest/host relationships in the synthesis of the novel cage-based zeolites SSZ-35, SSZ-36, and SSZ-39

Here, we report the synthesis and structure of three high-silica molecular sieves, SSZ-35, SSZ-36, and SSZ-39, that are prepared from a library of 37 different cyclic and polycyclic quaternized amine molecules that are used as structure-directing agents (SDAs). The size and shape of the quaternized amine molecules are purposely designed in order to obtain novel zeolite structures, and the synthesis of these molecules is presented. The selectivity for the three molecular sieve phases is found to depend on both the SDA and the degree of heteroatom lattice substitution of Al3+ or B3+ in the silicate framework. Molecular modeling is utilized to probe the effects of the nonbonded SDA/zeolite-framework interaction energy on the selectivity for the observed molecular sieve phase. The Rietveld refinement of the powder X-ray data confirms the structure of the SSZ-39 zeolite to be isomorphous with the aluminophosphate molecular sieve, SAPO-18 (AEI). The structure of SSZ-36 is found to possess a range of fault probabilities between the two-dimensional channel system, end-member polymorphs, ITQ-3 and RUB-13 (International Zeolite Association Codes ITE and RTH, respectively). The SSZ-35 structure is reported to contain a one-dimensional pore system possessing stacked cages circumscribed by alternating rings of 10 and 18 tetrahedral atoms (10- and 18-membered rings).

Synthesis and 1,3-Dipolar Cycloaddition Reaction of Homoadamantane-Incorporated Nitrones and Rearrangement of the Cycloadducts to Homoadamantane-Fused Pyrroles

The bridging nitrones 7, 8 incorporated in a homoadamantane ring system were obtained by oxidation of 4-azahomoadamantane 5, 6 with SeO2/H2O2.The 1,3-dipolar cycloaddition reaction of these nitrones with the electron-deficient alkynes proceeded regiospeci

Substituted 4-azatricyclo[4.3.1.13,8 ]undecane compounds

5-Substituted and/or N-Substituted 4-azatricyclo [4.3.1.13,8 ]undecane and 4-azatricyclo[4.3.1.13,8 ]undecan-5-one compounds are prepared.