22778-17-2Relevant academic research and scientific papers
Efficient continuous-flow HD exchange reaction of aromatic nuclei in D2O/2-PrOH mixed solvent in a catalyst cartridge packed with platinum on carbon beads
Park, Kwihwan,Ito, Naoya,Yamada, Tsuyoshi,Sajiki, Hironao
supporting information, p. 600 - 605 (2021/03/29)
Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/ CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60 s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.
Platinum on carbon-catalyzed H-D exchange reaction of aromatic nuclei due to isopropyl alcohol-mediated self- activation of platinum metal in deuterium oxide
Sawama, Yoshinari,Yamada, Tsuyoshi,Yabe, Yuki,Morita, Kosuke,Shibata, Kyoshiro,Shigetsura, Masahiro,Monguchi, Yasunari,Sajiki, Hironao
supporting information, p. 1529 - 1534 (2013/06/27)
An efficient and simple deuteration method of arenes using the platinum on carbon-isopropyl alcohol-cyclohexane-deuterium oxide combination under hydrogen gas-free conditions was accomplished. Since the hydrogen-deuterium exchange reaction cannot be promoted without isopropyl alcohol, zerovalent platinum metal (on carbon) is self-activated by the in situ-generated very low amount of hydrogen or hydrogen-deuterium gas derived from isopropyl alcohol or isopropyl alcohol-d1. Deuterium-labeled compounds with high deuterium contents can be easily isolated by the filtration of platinum on carbon and simple extraction. The present hydrogen gas-free method is safe from the viewpoint of process chemistry and various arenes possessing a variety of reducible functionalities within the molecule could be effectively and directly deuterium-labeled without undesired reduction. Copyright
DEUTERATED N-ETHYL-N-PHENYL-1,2-DIHYDRO-4-HYDROXY-5-CHLORO-1-METHYL-2-OXOQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF
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Page/Page column 8; 9, (2012/01/15)
The subject invention provides deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, its salts and uses.
