22779-02-8

Basic information

• Product Name: 4-ethynyl-1,3,5-trimethyl-1H-pyrazole
• Synonyms: 4-ethynyl-1,3,5-trimethyl-1H-pyrazole
• CAS NO: 22779-02-8
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.1784
• Mol File: 22779-02-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethynyl-1,3,5-trimethyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethynyl-1,3,5-trimethyl-1H-pyrazole(22779-02-8)
• EPA Substance Registry System: 4-ethynyl-1,3,5-trimethyl-1H-pyrazole(22779-02-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 22779-02-8(Hazardous Substances Data)

Upstream product

• 51660-65-2 4-iodo-1,3,5-trimethyl-1H-pyrazole 
• 2033-45-6 4-iodo-3,5-dimethyl-1H-pyrazole 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 74-86-2 acetylene 

Relevant articles and documents

Deprotonation of 4-ethynylpyrazolium salts

4-Ethynyl-1,2-dimethylpyrazolium salts were prepared by methylation of the corresponding 4-ethynyl-1-methylpyrazoles with trimethyloxonium tetrafluoroborate and were deprotonated to give the corresponding pyrazolium-4acetylenides, which are mesomeric betaines. These can be represented as alkynyl- or mesoionic allenylidene-type resonance forms. Calculations and spectroscopic investigations were performed to determine the contribution of each canonical form to the overall structure. Ylides and N-heterocyclic carbenes are tautomers of the betaines. Their relative stabilities have been compared.

HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.