22779-13-1

Upstream product

• 109-04-6 2-bromo-pyridine 
• 117635-52-6 5-Hydroxy-5-methyl-1-(4-methoxylphenyl)hexa-1,3-diyne 
• 29768-04-5 5-Hydroxy-5-methyl-1-(2-pyridinyl)hexa-1,3-diyne 
• 696-62-8 para-iodoanisole 
• 1945-84-2 2-ethynylpyridine 
• 768-60-5 4-methoxyphenylacetylen 
• 218431-37-9 2-(2-bromoethynyl)pyridine 

Downstream Products

• 141511-40-2 2-[5-(4-Methoxy-phenyl)-[1,2]dithiol-(3Z)-ylidenemethyl]-pyridine 
• 141511-45-7 5-(4-Methoxy-phenyl)-3-pyridin-2-yl-7λ⁴-[1,2]dithiolo[1,5-b][1,2,5]oxathiazole 

Relevant academic research and scientific papers

A convenient route to 1,3-diynes using ligand-free Cadiot–Chodkiewicz coupling reaction at room temperature under aerobic conditions

In this study, we report a copper-catalyzed ligand-free Cadiot–Chodkiewicz coupling reaction. No additives or ligands are required for this Cu-catalyzed C(sp)–C(sp) coupling reaction of terminal alkynes with alkynyl halides. The low cost of copper catalyst, excellent yield of the products, suppression of side-products and mild reaction conditions are the major advantages of this protocol.

Novel Synyhesis of Unsymmetrical Diarylbutadiynes

Terminal arylbutadiynes, derived from 6-aryl-3,5-hexadin-2-ols, undergo a ready palladium-catalyzed coupling with activated aryl halides in the presence of a phase transfer catalyst to unsymmetrical diarylbutadiynes, not easily available by other coupling