22780-52-5

Usage

Uses

Used in Organic Synthesis:
3-Amino-1H-isoindole is used as a building block in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-Amino-1H-isoindole is utilized as an intermediate, contributing to the development of new drugs and pharmaceuticals by aiding in the synthesis of complex molecules.
Used in Dye and Pigment Production:
3-Amino-1H-isoindole is employed as an intermediate in the production of dyes and pigments, where its chemical properties are leveraged to create a spectrum of colorants for various applications.
Used in Industrial Applications:
3-AMino-1H-isoindole is also used in industrial applications, where its unique structure and properties are harnessed to develop new materials and compounds that meet specific industry needs.
Used in Scientific Research:
3-Amino-1H-isoindole is utilized in scientific research to explore its potential in creating new compounds and materials, further expanding its applications across different scientific disciplines.

Upstream product

• 22115-41-9 2-(bromomethyl)benzonitrile 
• 157117-83-4 2-<(2-Cyan-phenyl)methyl>-2H-isoindol-1,3-dion 
• 1074-82-4 potassium phtalimide 
• 1207507-57-0 1-amino-3H-isoindole hydrobromide 
• 20377-03-1 4-azidoisoquinoline 
• 95605-79-1 5,5-dimethoxy-4,5-dihydro-1H-2,4-benzodiazepine 
• 81675-06-1 5-methoxy-1H-2,4-benzodiazepine 
• 40508-03-0 2-(azidomethyl)benzonitrile 

Downstream Products

• 87773-20-4 N-phenacyl phthalimidine 
• 61001-46-5 2-phenyl-5H-imidazo<2,1-a>isoindole hydrochloride 
• 61001-00-1 2-phenyl-5H-imidazo<2,1-a>isoindole 
• 1180486-10-5 2-(1-imino-1,3-dihydroisoindol-2-yl)-1-(3-pentafluorosulfanylphenyl)ethanone hydrobromide 
• 97934-39-9 1-[11H,13H-Benzo[5,6][1,3]diazepino[2,1-a]isoindol-(6E)-ylidene]-3-phenyl-thiourea 
• 97934-38-8 1-[11H,13H-Benzo[5,6][1,3]diazepino[2,1-a]isoindol-(6E)-ylidene]-3-phenyl-urea 
• 97934-35-5 hydrochloride of 2-(o-cyanobenzyl)-1-imino-3H-isoindole 

Relevant academic research and scientific papers

Imidazole derivatives as PDE10A enzyme inhibitors

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr

SF5 DERIVATIVES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS

The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R9, Ar, Q1, Q2 and Q3 are each as defined below. The compounds of the formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of the formula I and to the use thereof as a medicament.

The Curtin-Hammett principle in action: 1-amino-3H-isoindole in cycloaddition reactions

Based on the spectral studies of 1-aminoisoindole we have observed that in solution the isoindolenine tautomer predominates. In spite of this fact but, taking into account the Curtin-Hammett principle, we undertaken the first study of the Diels-Alder reaction for 1-aminoisoindole as a typical representative of simple isoindoles in isoindoline form. We have studied the interaction of 1-aminoisoindole with maleimide derivates and demonstrated that the products are rearranged 1:2 composition adducts. We have proposed a rearrangement mechanism, detected and identified the intermediate Diels-Alder products containing both endo- and exo adducts.

Reaction of azides with dichloroindium hydride: Very mild production of amines and pyrrolidin-2-imines through possible indium-aminyl radicals

Organic azides are easily reduced to the corresponding amines by reaction with dichloroindium hydride under very mild conditions and in a highly chemoselective fashion. γ-Azidonitriles give rise to outstanding five-membered cyclizations affording pyrrolidin-2-imines. A rationalization of the overall experimental data cannot exclude the occurrence of competitive radical and nonradical pathways, but certain results are, however, soundly consistent with the intermediacy of indium-bound nitrogen-centered radicals.

Cyclizations of N-Stannylaminyl Radicals onto Nitriles

(Matrix presented) Stannylaminyl radicals derived from radical reactions of Bu3SnH with azidoalkylmalononitriles exhibit highly efficient 5- and 6-exo cyclization onto either nitrile group to give aminoiminyl radicals that in turn are reduced t

SYNTHESIS AND CHARACTERIZATION OF 1H-2,4-BENZODIAZEPINES

Photolysis of the 4-azidoizoquinolines (1) in the presence of sodium methoxide afforded the 1H-2,4-benzodiazepines (3); this new ring system was characterized by some photochemical and thermal reactions.