22780-52-5Relevant articles and documents
Imidazole derivatives as PDE10A enzyme inhibitors
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Page/Page column 9, (2012/06/01)
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr
The Curtin-Hammett principle in action: 1-amino-3H-isoindole in cycloaddition reactions
Levkov, Igor V.,Turov, Oleksandr V.,Shishkin, Oleg V.,Shishkina, Svetlana V.,Voitenko, Zoia V.
experimental part, p. 508 - 512 (2010/03/03)
Based on the spectral studies of 1-aminoisoindole we have observed that in solution the isoindolenine tautomer predominates. In spite of this fact but, taking into account the Curtin-Hammett principle, we undertaken the first study of the Diels-Alder reaction for 1-aminoisoindole as a typical representative of simple isoindoles in isoindoline form. We have studied the interaction of 1-aminoisoindole with maleimide derivates and demonstrated that the products are rearranged 1:2 composition adducts. We have proposed a rearrangement mechanism, detected and identified the intermediate Diels-Alder products containing both endo- and exo adducts.
Cyclizations of N-Stannylaminyl Radicals onto Nitriles
Benati, Luisa,Bencivenni, Giorgio,Leardini, Rino,Minozzi, Matteo,Nanni, Daniele,Scialpi, Rosanna,Spagnolo, Piero,Zanardi, Giuseppe,Rizzoli, Corrado
, p. 417 - 420 (2007/10/03)
(Matrix presented) Stannylaminyl radicals derived from radical reactions of Bu3SnH with azidoalkylmalononitriles exhibit highly efficient 5- and 6-exo cyclization onto either nitrile group to give aminoiminyl radicals that in turn are reduced t