227804-34-4

Usage

Uses

Used in Pharmaceutical Research:
DMHM is utilized as a research compound for the development of new pharmaceuticals, targeting conditions like cancer and neurodegenerative diseases. Its potential pharmacological activity makes it a valuable candidate for further investigation and synthesis into more effective treatments.
Used in Organic Synthesis:
In the field of organic chemistry, DMHM serves as a precursor and intermediate in the synthesis of other organic compounds. Its unique structure and reactivity contribute to the creation of a variety of chemical products, expanding the scope of chemical research and development.

Upstream product

• 31874-34-7 (E)-2,4-dimethoxybenzaldehyde oxime 
• 31874-34-7 2,4-dimethoxybenzaldoxime 

Downstream Products

• 227804-36-6 C₁₂H₁₇NO₃ 
• 227804-40-2 C₁₄H₂₁NO₃ 
• 260441-20-1 N-(2,4-dimethoxybenzyloxy)-3-[4-(4-fluorophenyl)piperazine-1-sulfonyl]-2-isobutylpropionamide 
• 227804-52-6 4-[tert-butoxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-6-methyl-hept-2-enoic acid tert-butyl ester 
• 227804-50-4 4-[tert-butoxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-methyl-hex-2-enoic acid tert-butyl ester 
• 227804-48-0 4-[tert-butoxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-hex-2-enoic acid tert-butyl ester 
• 227804-46-8 4-[(2,4-dimethoxy-benzyl)-hydroxy-amino]-6-methyl-hept-2-ynoic acid tert-butyl ester 
• 227804-44-6 4-[(2,4-dimethoxy-benzyl)-hydroxy-amino]-5-methyl-hex-2-ynoic acid tert-butyl ester 
• 227804-42-4 4-[(2,4-dimethoxy-benzyl)-hydroxy-amino]-hex-2-ynoic acid tert-butyl ester 
• 1027383-14-7 4-(2,4-dimethoxy-benzylamino)-6-methyl-hept-2-enoic acid tert-butyl ester 
• 433711-86-5 C₂₂H₃₆N₂O₆ 
• 227804-38-8 C₁₃H₁₉NO₃ 

Relevant academic research and scientific papers

A Threonine-Forming Oxazetidine Amino Acid for the Chemical Synthesis of Proteins through KAHA Ligation

α-Ketoacid-hydroxylamine (KAHA) ligation allows the coupling of unprotected peptide segments through the chemoselective formation of an amide bond. Currently, the most widely used variant employs a 5-membered cyclic hydroxylamine that forms a homoserine ester as the primary ligation product. In order to directly form amide-linked threonine residues at the ligation site, we prepared a new 4-membered cyclic hydroxylamine building block. This monomer was applied to the synthesis of wild-type ubiquitin-conjugating enzyme UbcH5a (146 residues) and Titin protein domain TI I27 (89 residues). Both the resulting UbcH5a and the variant with two homoserine residues showed identical activity to a recombinant variant in a ubiquitination assay.

CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines

This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials. Readily accessed ally

Primary hydroxylamines and uses thereof

The present invention relates to primary hydroxylamines, to pharmaceutical compositions comprising them, to their use in the treatment and/or prevention of bacterial infections and to their use in the prevention of formation or reduction of formed biofilm

An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations

Amide-forming ligation reactions allow the chemical synthesis of proteins by the union of unprotected peptide segments, and enable the preparation of protein derivatives not accessible by expression or bioengineering approaches. The native chemical ligati

Synthesis of Z-α,β-ethylenic N-boc-γ-amino esters from nitrones

The reduction of γ-N-hydroxylamino-α,β-acetylenic esters bearing a methoxy-substituted benzyl group on the nitrogen atom by zinc in a MeOH/AcOH mixture leads stereoselectively to Z-γ-amino-α,β-ethylenic esters.