22794-86-1

Basic information

• Product Name: 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-methoxyphenyl)ethan-1-one
• Synonyms: 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-methoxyphenyl)ethan-1-one
• CAS NO: 22794-86-1
• Molecular Weight: 298.365
• Mol File: 22794-86-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-methoxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-methoxyphenyl)ethan-1-one(22794-86-1)
• EPA Substance Registry System: 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-methoxyphenyl)ethan-1-one(22794-86-1)

Safety Data

• Hazardous Substances Data: 22794-86-1(Hazardous Substances Data)

Upstream product

• 134469-07-1 Benzimidazol-2-thiol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 95-54-5 1,2-diamino-benzene 
• 174621-79-5 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile 

Relevant articles and documents

2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones: Synthesis, crystal study and cancer stem cells CD133 targeting potential

In order to develop a potent anti-tumor agent that can target both cancer stem cells and the bulk of tumor cells, a series of 2-((benzimidazol-2-yl)thio)-1-arylethan-1-ones 5a-o was synthesized. All compounds were evaluated for their anti-proliferative activity towards colon HT-29 cancer cell line. In addition, their inhibitory effect against cell surface expression of CD133, a potent cancer stem cells (CSCs) marker, in the same cells was evaluated by flow cytometry at 10 μM. Compound 5l emerged as the most active anti-proliferative analog against HT-29 (IC50 Combining double low line 18.83 ± 1.37 μM), that almost equipotent as 5-fluorouracil (IC50 Combining double low line 15.83 ± 1.63 μM) with 50.11 ± 4.05% inhibition effect on CD133 expression, suggested dual targeted effect. Also, compounds 5h, 5j, 5k and 5m-o inhibited the expression of CD133 with more than 50%. The SAR study pointed out the significance of substitution of the pendent phenyl group with lipophilic electron-donating groups or replacing it by 2-thienyl or 2-furyl groups.

Synthesis, In Vitro α-Amylase Activity, and Molecular Docking Study of New Benzimidazole Derivatives

Abstract: New benzimidazole derivatives were synthesized by reacting substitutedphenacyl bromides with 1H-benzimidazole-2-thiols. The synthesized compounds werecharacterized through 1H and13C NMR and high-resolution mass spectra. The

A facile one pot synthesis of thiazolo[3,2-: A] benzimidazole and pyran fused polyheterocyclic scaffolds

An efficient synthesis of dihydro-4H-benzo[4,5]imidazo[2,1-b]pyrano[2,3-d]thiazole by a multicomponent route starting from 2-((1H-benzo[d]imidazol-2-yl)thio)-1-phenylethan-1-one, an aromatic aldehyde and malononitrile is described. This protocol features