227959-44-6

Basic information

• Product Name: 3-(diethoxymethyl-ethoxy-phosphinoyl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester
• Synonyms: 3-(diethoxymethyl-ethoxy-phosphinoyl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 227959-44-6
• Molecular Weight: 429.45
• Mol File: 227959-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(diethoxymethyl-ethoxy-phosphinoyl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diethoxymethyl-ethoxy-phosphinoyl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester(227959-44-6)
• EPA Substance Registry System: 3-(diethoxymethyl-ethoxy-phosphinoyl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester(227959-44-6)

Safety Data

• Hazardous Substances Data: 227959-44-6(Hazardous Substances Data)

Upstream product

• 95798-22-4 3-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 6859-99-0 3-hydroxypiperazine 
• 61995-20-8 N-(benzyloxycarbonyl)-3-piperidone 
• 65600-74-0 ethyl diethoxymethylphosphinate 

Downstream Products

• 227959-48-0 3-(diethoxymethyl-ethoxy-phosphinoyl)-piperidine-1-carboxylic acid benzyl ester 
• 227959-46-8 oxalic acid 1-benzyloxycarbonyl-3-(diethoxymethyl-ethoxy-phosphinoyl)-piperidin-3-yl ester methyl ester 

Relevant articles and documents

Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter γ-aminobutyric acid (GABA)

Piperidinyl-3-phosphinic acid 2, piperidinyl-3-methylphosphinic acid 3 and N-(4,4-diphenyl-3-butenyl)-piperidinyl-3-phosphinic acid 4 have been synthesized as bioisosteres of the corresponding amino carboxylic acids, which are potent and specific GABA-uptake inhibitors. The novel amino phosphinic acids were tested for their GABA-uptake inhibitory activity and 2 and 4 were identified as the first phosphinic acid based GABA-uptake inhibitors. The methylphosphinic acid 3 was found to be inactive.