228113-61-9Relevant academic research and scientific papers
Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
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Page column 22-23, 28, (2010/01/31)
A process for preparing enantiomerically enriched tetrahydrobenzothipeine oxides comprises cyclizing an enantiomerically enriched aryl-3-propanalsulfoxide wherein the sulfur atom of the aryl-3-propanalsulfoxide is a chiral center.
A highly enantioselective benzothiepine synthesis
Wang, Ching-Cheng,Li, James J.,Huang, Horng-Chih,Lee, Len F.,Reitz, David B.
, p. 2711 - 2715 (2007/10/03)
A highly enantioselective synthesis of benzothiepine 1a has been accomplished via an enantioen-riched sulfoxide intermediate obtained by asymmetric oxidation with a chiral oxaziridine in 89:11 er. The key step is a thermodynamically controlled asymmetric cyclization reaction that produces two new stereogenic centers. The (4R,5R) isomer 1a was obtained in 98:2 er.
