22818-43-5

Basic information

• Product Name: L-BETA-HOMOLEUCINE
• Synonyms: L-BETA-HOMOLEUCINE;H-LEU-(C*CH2)OH;(3S)-3-AMINO-5-METHYL-HEXANOIC ACID;(S)-3-AMINO-5-METHYL-HEXANOIC ACID;L-β-Homoleucine, HPLC 98%;(3S)-3-Isobutyl-β-alanine;(S)-3-Isobutyl-β-alanine;L-3-Amino-5-methylhexanoic acid
• CAS NO: 22818-43-5
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 22818-43-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 222-224 °C
• Boiling Point: 249.115 °C at 760 mmHg
• Flash Point: 104.461 °C
• Appearance: /
• Density: 1.014 g/cm³
• Vapor Pressure: 0.00744mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.81±0.10(Predicted)
• CAS DataBase Reference: L-BETA-HOMOLEUCINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-BETA-HOMOLEUCINE(22818-43-5)
• EPA Substance Registry System: L-BETA-HOMOLEUCINE(22818-43-5)

Safety Data

• Hazardous Substances Data: 22818-43-5(Hazardous Substances Data)

Usage

General Description

L-BETA-HOMOLEUCINE is an unnatural amino acid that is structurally similar to the essential amino acid leucine. It is commonly used in the study of protein structure and function due to its ability to incorporate into proteins and interfere with their normal function. L-BETA-HOMOLEUCINE has been investigated for its potential use in the treatment of neurological disorders, as it is believed to act as an inhibitor of the enzyme glutamate dehydrogenase and modulate glutamate levels in the brain. Additionally, it has been explored for its potential use in the development of new antibiotics and antitumor agents. Overall, L-BETA-HOMOLEUCINE shows promise as a versatile chemical with various potential applications in medical and scientific research.

InChI:InChI=1/C7H15NO2/c1-5(2)3-6(8)4-7(9)10/h5-6H,3-4,8H2,1-2H3,(H,9,10)/t6-/m0/s1

Upstream product

• 96813-23-9 (N-Phthaloyl-L-leucyl)diazomethane 
• 3653-34-7 3-amino-5-methylhexanoic acid 
• 34036-16-3 5-methyl-3-oxo-hexanoic acid ethyl ester 
• 193887-44-4 (S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-methylhexanoic acid 
• 22818-41-3 L-β-Tosylamino-isooenanthsaeureamid, (S)-3-Tosylamino-5-methyl-capronsaeureamid 
• 99189-71-6 (S)-3-isocyanato-5-methyl-hexanoic acid ethyl ester 
• 2419-38-7 N-phthaloyl-(S)-leucine 
• 108-12-3 isopentanoyl chloride 
• 136744-87-1 (E)-methyl 3-acetamido-5-methyl-2-hexenoate 
• 136744-81-5 methyl 3-amino-5-methyl-2-hexenoate 
• 30414-55-2 methyl 5-methyl-3-oxohexanoate 
• 146398-15-4 (S)-tert-butyl 3-<(benzyloxycarbonyl)amino>-5-methylhexanoate 
• 112157-30-9 (2S)-2-<(tert-butyloxycarbonyl)amino>-1-<(p-tolylsulfonyl)oxy>-4-methylpentane 
• 82010-31-9 (S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester 

Downstream Products

• 109510-47-6 (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methylhexanoic acid 
• 90726-94-6 (S)-3-amino-5-methyl-hexanoic acid ethyl ester 
• 138165-75-0 N-Boc-L-β-homoleucine 
• 215608-35-8 methyl (S)-4-<(benzyloxycarbonyl)amino>-6-methyl-2-oxoheptanoate 
• 78175-25-4 (S)-3-(2,4-Dinitro-phenylamino)-5-methyl-hexanoic acid (4-methoxy-phenyl)-amide 
• 118247-68-0 N-Benzyloxycarbonyl-L-Homoleucine 
• 78175-30-1 (S)-3-(2,4-Dinitro-phenylamino)-5-methyl-hexanoic acid 
• 101270-20-6 (S)-5-methyl-3-(N'-phenyl-ureido)-hexanoic acid ethyl ester 
• 101739-99-5 (S)-3-(N'-benzyl-ureido)-5-methyl-hexanoic acid ethyl ester 
• 107417-86-7 (S)-3-benzyl-6-isobutyl-dihydro-pyrimidine-2,4-dione 
• 220116-79-0 (2S,6S)-2-tert-Butyl-6-isobutyl-4-oxo-tetrahydro-pyrimidine-1-carboxylic acid benzyl ester 
• 220116-78-9 (2R,6S)-2-tert-Butyl-6-isobutyl-4-oxo-tetrahydro-pyrimidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Preparation method of 3-aminopropanol or 3-aminopropionic acid derivative

The invention provides a preparation method of an optically active 3-aminopropanol or 3-aminopropionic acid derivative, and belongs to the technical field of organic synthesis. A compound having a structure as shown in a formula II and a formula III is used as a raw material, and the optically active 3-aminopropanol or 3-aminopropionic acid derivative is obtained through four basic steps, namely dehydration condensation, hydrogenation reduction, reduction and hydrolysis. The raw materials adopted in the preparation method are easy to obtain and low in cost; as a chiral phosphine-transitional metal catalyst is used in the hydrogenation reduction reaction, the optically active 3-aminopropanol or 3-aminopropionic acid derivative is efficient, high in selectivity, low in cost and suitable forlarge-scale production. Compared with existing chemical resolution and chiral introduction, the asymmetric hydrogenation synthesis method provided by the invention only produces one chiral product, ishigh in yield, and has relatively high advantages in economy and raw material utilization rate.

METHOD FOR OBTAINING OPTICALLY PURE AMINO ACIDS

This invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. This method significantly shortens the time taken for optical transformation, and enables the repeated use of an organic solution containing a enantioselective receptor, to thereby obtain optically pure amino acids in a simple and remarkably efficient manner, and to enable the very economical mass production of optically pure amino acids.

Thermal cleavage of the Fmoc protection group

The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.