228247-99-2

Basic information

• Product Name: (E)-3-Cyclohex-1-enyl-acrylic acid (Z)-1-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynyl ester
• CAS NO: 228247-99-2
• Molecular Weight: 344.451
• Mol File: 228247-99-2.mol

Chemical Properties

• CAS DataBase Reference: (E)-3-Cyclohex-1-enyl-acrylic acid (Z)-1-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Cyclohex-1-enyl-acrylic acid (Z)-1-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynyl ester(228247-99-2)
• EPA Substance Registry System: (E)-3-Cyclohex-1-enyl-acrylic acid (Z)-1-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynyl ester(228247-99-2)

Safety Data

• Hazardous Substances Data: 228247-99-2(Hazardous Substances Data)

Upstream product

• 6089-04-9 3-(tetrahydropyran-2'-yloxy)propyne 
• 56453-88-4 (E)-3-(1-cyclohexen-1-yl)-2-propenoic acid 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists

A parallel synthesis of racemic himbacine analogs was carried out by N- alkylation of various commercially available cyclic amine derivatives with the alkylating agent 4 which bears the tricyclic unit of himbacine. Several of these analogs have potency comparable to that of himbacine, albeit lacking the desired selectivity. Structure-activity relationship studies support the existence of a hydrophobic pocket in the receptor where the piperidine ring of dihydrohimbacine binds.