228259-02-7

Upstream product

• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 

Downstream Products

• 228259-13-0 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole 
• 885024-24-8 2-[6-(4-iodo-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxy-benzoic acid methyl ester 
• 228259-21-0 2-(2-aminomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide 
• 228259-20-9 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide 
• 228259-24-3 2-(2-azidomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide 
• 228259-22-1 2-(2-azidomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide 
• 228259-23-2 2-(2-azidomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-methanesulfonyl-biphenyl-4-yl)-amide 
• 228259-15-2 methanesulfonic acid 2-(5-furan-2-yl-3-trifluoromethyl-pyrazol-1-yl)-5-methoxy-benzyl ester 
• 228259-17-4 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole 
• 228259-19-6 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride 
• 228259-18-5 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid 
• 228259-14-1 1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole 
• 228259-05-0 ethyl 1-(2-hydroxymethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.

Pyrazolobenzamides and derivatives as factor Xa inhibitors

The present application describes pyrazolobenzamides and derivatives thereof of Formula I: [in-line-formulae]P4-P-M-M4??I [/in-line-formulae] or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2′ -(aminosulfonyl)[1,1′-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recentl

Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors

The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho to G on E