2283-96-7Relevant academic research and scientific papers
Intramolecular Pd(0)-catalyzed reactions of β-(2-iodoanilino) carboxamides: Enolate arylation and nucleophilic substitution at the carboxamide group
Sole, Daniel,Serrano, Olga
scheme or table, p. 9372 - 9378 (2009/04/10)
(Chemical Equation Presented) Two different reaction pathways, the enolate arylation and the acylation of the aryl halide, can be promoted by a Pd(0) catalyst starting from β-(2-iodoanilino) carboxamides. The intramolecular acylation of β-(2-iodoanilino) carboxamides reported here is the first example of a nucleophilic attack of a σ-arylpalladium species at the carboxamide group, a framework that is usually inert toward organopalladium reagents.
