22839-66-3

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 125507-04-2 (S)-2-{[5-Chloro-5-cyano-2-((S)-1-phenyl-ethyl)-isoxazolidine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 125507-04-2 (S)-2-{[5-Chloro-5-cyano-2-((R)-1-phenyl-ethyl)-isoxazolidine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 125507-02-0 C₂₀H₂₂N₂O₄ 
• 125507-02-0 C₂₀H₂₂N₂O₄ 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 125507-07-5 (S)-2-{[(R)-5-Oxo-2-((S)-1-phenyl-ethyl)-isoxazolidine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 125507-07-5 (S)-2-{[(R)-5-Oxo-2-((R)-1-phenyl-ethyl)-isoxazolidine-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 104638-46-2 N-phenacetyl-D-L-aspartame 
• 125507-05-3 (S)-2-[(2-Benzyl-5-oxo-isoxazolidine-3-carbonyl)-amino]-3-phenyl-propionic acid methyl ester 
• 22839-59-4 3-benzyloxycarbonylamino-N-(1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester 

Downstream Products

• 142955-73-5 3-Hydroxy-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid 
• 142955-73-5 3-Hydroxy-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid 

Relevant academic research and scientific papers

STEREOCONTROLLED SYNTHESES OF ASPARTAME AND ITS (R)-ASPARTYL CONGENER VIA NITRONE CYCLOADDITION

The title compounds have been synthesised via cycloaddition of nitrones (3a,b,c) to 2-chloroacrylonitrile.

IMMOBILIZED PENICILLINACYLASE: APPLICATION TO THE SYNTHESIS OF THE DIPEPTIDE ASPARTAME

Immobilized penicillinacylase efficently catalyzes the conversion at pH 7.5 of N-phenacetyl aspartame (4) into aspartame (2) and phenylacetic acid.