228410-48-8

Upstream product

• 21901-18-8 4-Methyl-3-nitro-2-pyridone 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 228408-75-1 3-[2'-(R,S)-(dimethyl)-naphthylacetylamino-3'-[4''-(1'''-carboxy-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 
• 228408-75-1 2-{4-[(S)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid 
• 228408-75-1 2-{4-[(R)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid 
• 356578-38-6 3-[2'-(S)-(1'''-naphthylacetyl)amino-3'-(4''-methoxycarbonylmethyl)benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 
• 356578-40-0 3-[2'-(R,S)-t-butoxycarbonylamino-3'-[4''-(1'''-t-butoxycarbonyl-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 
• 356578-34-2 3-[2'-(S)-t-butoxycarbonylamino-3'-(4''-methoxycarbonylmethyl)benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 
• 356578-39-7 (4-{(S)-2-Acetylamino-2-[1-(4-methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-ethyl}-phenyl)-acetic acid methyl ester 
• 356578-41-1 2-(4-{2-amino-2-[1-(4-methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-ethyl}-phenyl)-2-methyl-propionic acid tert-butyl ester 
• 356578-36-4 3-[2'-(S)-amino-3-(4''-methoxycarbonylmethyl)benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 
• 228410-49-9 3-amino-1-(4-methoxybenzyl)-4-methyl-2-pyridone 

Relevant academic research and scientific papers

Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain

p56lck is a member of the src family of tyrosine kinases and plays a critical role in the signal transduction events that lead to T cell activation. Ligands for the p56lck SH2 domain have the potential to disrupt the interaction of p56lck with its substra

Src family SH2 domain inhibitors

This invention relates to compounds of formula (1): wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.