228412-12-2Relevant articles and documents
Stereoselective synthesis of inositol mono, bis and trisphosphate analogue from 6-deoxy-D-inositol precursors
Vieira de Almeida, Mauro,Dubreuil, Didier,Cleophax, Jeannine,Verre-Sebrie, Catherine,Pipelier, Muriel,Prestat, Guillaume,Vass, Georges,Gero, Stephane D.
, p. 7251 - 7270 (2007/10/03)
The synthesis of opticaly pure deoxy-myo-inositol mono, bis and trisphosphate analogues is described from 4-O-benzyl-2,3-di-O- cyclohexylidene-6-deoxy-myo-inositol and corresponding 1,5 epimer chiro- inositol. These precursors, which derive from galactose, are used to accede to a variety of cyclitol intermediates employing protection/deprotection sequence. The phosphorylation procedure was performed to produce free and original substituted phosphate derivatives aimed to be incorporated through the lipidic cell membrane for in vivo evaluation.