228421-83-8

Basic information

• Product Name: 3,5-difluoro-4-(hydroxymethyl)benzonitrile
• Synonyms: 3,5-difluoro-4-(hydroxymethyl)benzonitrile;3,5-Difluoro-4-(hydroxymethyl)
• CAS NO: 228421-83-8
• Molecular Formula: C₈H₅F₂NO
• Molecular Weight: 169.1282064
• Mol File: 228421-83-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 272.559°C at 760 mmHg
• Flash Point: 118.64°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.04±0.10(Predicted)
• CAS DataBase Reference: 3,5-difluoro-4-(hydroxymethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-difluoro-4-(hydroxymethyl)benzonitrile(228421-83-8)
• EPA Substance Registry System: 3,5-difluoro-4-(hydroxymethyl)benzonitrile(228421-83-8)

Safety Data

• Hazardous Substances Data: 228421-83-8(Hazardous Substances Data)

Usage

General Description

3,5-difluoro-4-(hydroxymethyl)benzonitrile is an organic compound with the molecular formula C8H5F2NO. It is a chemical intermediate used in the synthesis of pharmaceuticals and agrochemicals. 3,5-difluoro-4-(hydroxymethyl)benzonitrile has two fluorine atoms at the 3 and 5 positions on the benzene ring, as well as a hydroxymethyl group at the 4 position and a benzonitrile group attached to the ring. It is used in the production of various compounds with potential applications in the pharmaceutical and agricultural industries. This chemical may have properties that make it useful for altering the biological activity of compounds for specific applications.

InChI:InChI=1/C8H5F2NO/c9-7-1-5(3-11)2-8(10)6(7)4-12/h1-2,12H,4H2

Upstream product

• 162744-59-4 (4-bromo-2,6-difluoro-phenyl)methanol 
• 557-21-1 zinc(II) cyanide 
• 467442-15-5 3,5-difluoro-4-formylbenzonitrile 

Downstream Products

• 1239956-70-7 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoic acid 
• 1239956-67-2 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzonitrile 
• 1239964-16-9 4-(bromomethyl)-3,5-difluorobenzonitrile 
• 633336-79-5 4-cyano-3,5-difluorobenzyl methanesulfonate 

Relevant articles and documents

OXADIAZOLE DERIVATIVES

The invention relates to compounds of formula (I); wherein R1, R2, Ra, Rb, W, Q and S have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple

NEW SALTS

There is provided pharmaceutically-acceptable acid addition salts of compounds of formula (I), wherein R1 represents C1-2 alkyl substituted by one or more fluoro substituents; R2 represents C1-2 alkyl; and n rep

MODIFIED RELEASE PHARMACEUTICAL FORMULATION

A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents;R2 represents hydrogen, hydroxy, methoxy