228422-49-9 Usage
Description
(S)-3-(4-FLUOROPHENYL)-BETA-ALANINOL is a chiral compound characterized by its specific stereochemistry, where the hydroxyl group is attached to the beta carbon of the alaninol moiety, and a 4-fluorophenyl group is attached to the same carbon. This unique structure endows it with potential applications in various fields, particularly in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(S)-3-(4-FLUOROPHENYL)-BETA-ALANINOL is used as a key intermediate in the synthesis of aminopyrimidine derivatives, which are known to modulate kinase activity. Kinases are enzymes that play a crucial role in cellular signaling pathways, and their dysregulation is often associated with various diseases, including cancer and inflammatory disorders. By modulating kinase activity, these aminopyrimidine derivatives can potentially be developed into therapeutic agents for the treatment of such diseases.
In the synthesis of these aminopyrimidine derivatives, (S)-3-(4-FLUOROPHENYL)-BETA-ALANINOL serves as a building block, providing the necessary structural elements for the formation of the desired compounds. Its chiral nature ensures that the final products have the correct stereochemistry, which is often critical for biological activity and selectivity.
Furthermore, the 4-fluorophenyl group in (S)-3-(4-FLUOROPHENYL)-BETA-ALANINOL can also contribute to the overall properties of the resulting aminopyrimidine derivatives, such as their lipophilicity, stability, and binding affinity to target kinases. This can be particularly important in the design of drugs with improved pharmacokinetic and pharmacodynamic profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 228422-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,8,4,2 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 228422-49:
(8*2)+(7*2)+(6*8)+(5*4)+(4*2)+(3*2)+(2*4)+(1*9)=129
129 % 10 = 9
So 228422-49-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H12FNO/c10-8-3-1-7(2-4-8)9(11)5-6-12/h1-4,9,12H,5-6,11H2/t9-/m0/s1
228422-49-9Relevant articles and documents
Method for producing chiral or enantiomer-enriched beta-amino acids, aldehydes, ketones and gama-amino alcohols
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, (2008/06/13)
The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical, a cycloalkyl rad
IMPROVED METHOD FOR PRODUCING CHIRAL OR ENANTIOMER-ENRICHED BETA-AMINO ACIDS, -ALDEHYDES, -KETONES AND GAMMA-AMINO ALCOHOLS
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Page/Page column 12, (2008/06/13)
The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical, a cycloalkyl rad
Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists
Guo, Zhiqiang,Wu, Dongpei,Zhu, Yun-Fei,Tucci, Fabio C.,Regan, Collin F.,Rowbottom, Martin W.,Struthers, R. Scott,Xie, Qiu,Reijmers, Shelby,Sullivan, Susan K.,Sai, Yang,Chen, Chen
, p. 3685 - 3690 (2007/10/03)
SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.
