228546-48-3Relevant academic research and scientific papers
A convergent synthesis of CGS23305, a thromboxane synthase inhibitor
Bach, Andrew T.,Carlson, John A.,Giannousis, Peter P.
, p. 769 - 774 (2007/10/03)
A convergent synthesis of CGS23305 was discovered. The route to the pyridine aldehyde intermediate 5 was reduced from four to two steps. The pyridine aldehyde was converted to the key pyridine aldehyde ester intermediate 7 via Michael Addition of the N,N-diethylenamine 6 to ethyl acrylate. A Wittig alkenation using the multifunctional moiety 19 completed the carbon skeleton assembly. Hydrogenation and hydrolysis afforded CGS23305 in 44% overall yield from 14 (6 steps).
