228574-87-6Relevant academic research and scientific papers
Identification and optimization of inhibitors of trypanosomal cysteine proteases: Cruzain, rhodesain, and TbCatB
Mott, Bryan T.,Ferreira, Rafaela S.,Simeonov, Anton,Jadhav, Ajit,Ang, Kenny Kean-Hooi,Leister, William,Shen, Min,Silveira, Julia T.,Doyle, Patricia S.,Arkin, Michelle R.,McKerrow, James H.,Inglese, James,Austin, Christopher P.,Thomas, Craig J.,Shoichet, Brian K.,Maloney, David J.
supporting information; experimental part, p. 52 - 60 (2010/04/29)
Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas' disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival: cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A rec
Discovery of new 1,3,5-triazine scaffolds with potent activityagainst Mycobacterium tuberculosis H37Rv
Sunduru, Naresh,Gupta, Leena,Chaturvedi, Vinita,Dwivedi, Richa,Sinha, Sudhir,Chauhan, Prem M.S.
experimental part, p. 3335 - 3345 (2010/08/06)
A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the ra
Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents
Kumar, Ashok,Srivastava, Kumkum,Raja Kumar,Puri,Chauhan, Prem M.S.
scheme or table, p. 6530 - 6533 (2009/09/06)
The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new class of hybrid 4-aminoquinoline triazines were synthesized and screened aga
