228579-02-0

Basic information

• Product Name: 2-[4-(3-Phenylpyrrolidin-1-yl)butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
• Synonyms: LB-50016
• CAS NO: 228579-02-0
• Molecular Formula: C₂₁H₂₄N₂O₃S
• Molecular Weight: 384.50103
• Mol File: 228579-02-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(3-Phenylpyrrolidin-1-yl)butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(3-Phenylpyrrolidin-1-yl)butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide(228579-02-0)
• EPA Substance Registry System: 2-[4-(3-Phenylpyrrolidin-1-yl)butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide(228579-02-0)

Safety Data

• Hazardous Substances Data: 228579-02-0(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 936-44-7 3-phenylpyrrolidine 
• 103564-59-6 N-[4-bromobutyl]saccharin 
• 1026-59-1 (rac)-N-benzyl-3-phenylpyrrolidine 

Relevant articles and documents

N-Substituted-3-arylpyrrolidines: Potent and Selective Ligands at Serotonin 1A Receptor

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.