2286-34-2

Usage

Derived From

Acrylic acid

Uses

Production of adhesives, coatings, and polymer resins

Functional Group

Cyano group (CN)

Versatility

Building block for synthesis of pharmaceuticals, agrochemicals, and fine chemicals

Stability

Known for its stability

Compatibility

Compatible with other materials

Applications

Widely used in the chemical industry

Handling

Requires careful handling and adherence to safety protocols

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 77198-37-9 3-Amino-2,4-dicyano-1-(4-isopropyl-phenyl)-1,2,6,7,8,8a-hexahydro-naphthalene-2-carboxylic acid ethyl ester 
• 1239897-49-4 C₂₇H₂₉ClN₂O₆ 
• 85663-43-0 2-{4-[3-(4-Fluoro-phenyl)-6-isopropyl-indan-1-yl]-piperazin-1-yl}-ethanol 
• 344447-25-2 3-Chloro-1-(4-fluoro-phenyl)-5-isopropyl-indan 
• 80272-14-6 3-(4-Fluoro-phenyl)-3-(4-isopropyl-phenyl)-propionic acid 
• 80272-36-2 3-(4-Fluoro-phenyl)-6-isopropyl-indan-1-one 

Relevant academic research and scientific papers

Mesoporous sodalite: A novel, stable solid catalyst for base-catalyzed organic transformations

Mesoporous sodalite with a mesoporous/microporous hierarchical structure was successfully synthesized using an organosilane surfactant. It showed about 10-fold high surface area and 4-fold large pore volume, as compared with sodalite with solely microporous structure. The basicity of MPSOD was higher than that of CsNaX or KAlMCM-41. The catalytic activities of this mesoporous zeolite were evaluated for various base catalyzed reactions involving bulky and small substrates, viz. Knoevenagel condensation, Claisen-Schmidt condensation in liquid phase, and acetonylacetone cyclization in vapor phase. The catalyst showed higher activity and longer lifetime than CsNaX and KAlMCM-41.

Microwave-assisted Knoevenagel condensation in aqueous over triazine-based microporous network

A high nitrogen-containing triazine-based microporous polymeric (TMP) network was used as an efficient metal-free catalyst for Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes. The reactions were performed in water as an environmental

Mesoporous carbon nitride as a metal-free base catalyst in the microwave assisted Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes

High nitrogen containing mesoporous carbon nitride (MCN) was synthesized and investigated as a metal-free base catalyst for the Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes. The catalyst was found to be efficient for the Knoevenag

Imidazolium chloride immobilized SBA-15 as a heterogenized organocatalyst for solvent free Knoevenagel condensation using microwave

Heterogeneous organocatalyst, 1-methyl-3-[(3-triethoxysilyl) propyl] imidazolium chloride [MTESPImCl] immobilized SBA-15 (ILS) was synthesized by co-condensation method using microwave irradiation in which 1-methylimidazole (Im) was modified by organosila

Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate

A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.

A straightforward method for the synthesis of alkylidene and arylidene malonates through proline-catalyzed Knoevenagel condensation

A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents.

Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans

A series of 1-piperazino-3-phenylindans was synthesized and tested for neuroleptic and thymoleptic activity. Neuroleptic activity was found only in trans racemates and was associated with one of the enantiomers only. The potent and long-acting neuroleptic compound trans-4-[3-(4-fluorophenyl)-6-(trifluoromethyl)indan-1-yl]-1-piperazineeth anol (Lu 18-012, tefludazine) was developed by systematic variation of structural components. Thymoleptic activity was optimized, especially with respect to dopamine-uptake inhibition. No geometrical stereoselectivity was found with regard to dopamine-uptake inhibition, but a high enantioselectivity could be demonstrated for both cis and trans racemates. The most potent compounds were 1-piperazino-3-(3,4-dichlorophenyl)indans with IC50 values of about 2 nM for inhibition of dopamine uptake.