22860-01-1

Basic information

• Product Name: Ethanone, 1-(2,4,6-trimethylphenyl)-, oxime
• CAS NO: 22860-01-1
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol File: 22860-01-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2,4,6-trimethylphenyl)-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2,4,6-trimethylphenyl)-, oxime(22860-01-1)
• EPA Substance Registry System: Ethanone, 1-(2,4,6-trimethylphenyl)-, oxime(22860-01-1)

Safety Data

• Hazardous Substances Data: 22860-01-1(Hazardous Substances Data)

Upstream product

• 79-24-3 Nitroethane 
• 108-67-8 1,3,5-trimethyl-benzene 
• 1667-01-2 2,4,6-Trimethylacetophenone 
• 1028432-18-9 C₂₄H₃₇NO₃SSi 

Relevant articles and documents

Self-catalyzed direct amidation of ketones: A sustainable procedure for acetaminophen synthesis

High yielding amination of ketones and benzaldehyde in acid-less conditions has been conducted on several ketones to achieve amides and nitriles. The reactivity of the selected substrates showed to depend on both oximation and Beckmann rearrangement reaction rates. Oximation allows the in-situ production of hydrochloric acid that enables Beckmann rearrangement of the oxime to form the corresponding amide or nitrile. It is noteworthy that, using this one-pot synthetic approach, N-acetyl-4-aminophenol (acetaminophen drug), can be easily synthesized starting from 4-hydroxy-acetophenone in high yield. Acetanilide and ε-caprolactam can be also efficiently synthesized employing this synthetic procedure.

O-TBS-N-tosylhydroxylamine: A reagent for facile conversion of alcohols to oximes

(Chemical Equation Presented) A variety of oximes were synthesized from the corresponding alcohols, alkyl halides, or alkyl sulfonates without using external oxidants. With this simple two-step procedure involving substitution with readily available TsNHOTBS and subsequent treatment with CsF, a range of oximes were prepared including the ones hardly preparable with conventional procedures.