22868-60-6

Basic information

• Product Name: 5-(1-piperidyl)furan-2-carbaldehyde
• Synonyms: 5-(1-piperidyl)furan-2-carbaldehyde;5-(1-PIPERIDINYL)-2-FURALDEHYDE;5-piperidin-1-yl-2-furaldehyde(SALTDATA: FREE);5-(1-piperidinyl)-2-Furancarboxaldehyde
• CAS NO: 22868-60-6
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: Aldehydes;Furans, Benzofurans & Dihydrobenzofurans;Furans, Benzofurans & Dihydrobenzofurans
• Mol File: 22868-60-6.mol

Chemical Properties

• Melting Point: 50.5-51.5 °C
• Boiling Point: 329.3°Cat760mmHg
• Flash Point: 153°C
• Appearance: /
• Density: 1.147g/cm³
• Vapor Pressure: 0.000179mmHg at 25°C
• Refractive Index: 1.554
• PKA: 1.57±0.20(Predicted)
• CAS DataBase Reference: 5-(1-piperidyl)furan-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-piperidyl)furan-2-carbaldehyde(22868-60-6)
• EPA Substance Registry System: 5-(1-piperidyl)furan-2-carbaldehyde(22868-60-6)

Safety Data

• Hazardous Substances Data: 22868-60-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-(1-piperidyl)furan-2-carbaldehyde is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups make it a versatile building block for creating new drugs and organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-(1-piperidyl)furan-2-carbaldehyde is used as a key component in the development of new drugs. Its biological activities, such as anti-inflammatory and antimicrobial properties, make it a promising candidate for the treatment of various diseases and conditions.
Used in Drug Development:
5-(1-piperidyl)furan-2-carbaldehyde is utilized in drug development for its potential to contribute to the creation of novel therapeutic agents. Its presence in research and development pipelines underscores its importance in advancing pharmaceutical innovation.
Used in Material and Chemical Product Development:
Beyond its pharmaceutical applications, 5-(1-piperidyl)furan-2-carbaldehyde is also used in the development of new materials and chemical products. Its chemical properties and reactivity make it a valuable component in various industrial applications, contributing to the advancement of material science and chemical engineering.

InChI:InChI=1/C10H13NO2/c12-8-9-4-5-10(13-9)11-6-2-1-3-7-11/h4-5,8H,1-3,6-7H2

Upstream product

• 31795-44-5 5-formyl-2-furansulfonic acid sodium salt 
• 110-89-4 piperidine 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 2689-65-8 5-iodofuran-2-carbaldehyde 

Downstream Products

• 84966-44-9 1-(3,5-Dinitrobenzoyloxy)-2-methyl-N-(5-piperidinofurfuryliden)-2-propanamin-N-oxid 
• 84966-55-2 <1-(Phenylcarbamoyloxy)cyclohexyl>-N-(5-piperidinofurfuryliden)methanamin-N-oxid 
• 84966-54-1 2-Methyl-1-(phenylcarbamoyloxy)-N-(5-piperidinofurfuryliden)-2-propanamin-N-oxid 
• 84966-21-2 2-Hydroxy-2-phenyl-N-(5-piperidinofurfuryliden)ethanamin-N-oxid 
• 84966-22-3 (1-Hydroxycyclohexyl)-N-(5-piperidinofurfuryliden)methanamin-N-oxid 
• 84966-45-0 1-Benzoyloxy-2-methyl-N-(5-piperidinofurfuryliden)-2-propanamin-N-oxid 

Relevant articles and documents

A facile preparation of trisubstituted amino-furan and -thiophene derivatives

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.

From furans to anilines: Toward one-pot two-step amination/Diels-Alder sequences

(Chemical Equation Presented) Selective metal-free amination and Diels-Alder reactions are described in the furan series, leading to polysubstituted anilines or to stable oxabicyclic adducts in high yield. Interestingly, anilines are conveniently prepared through a novel one-pot, two-step amination/Diels-Alder procedure from commercially available 5-bromo-2-furaldehyde.

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re

Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media

We describe herein a new amination procedure of weakly activated heterocyclic bromo derivatives in aqueous media. The base catalysed mechanism of this reaction is also confirmed. Moreover, the application of this strategy to the preparation of amino furans and selenophenes is outlined.

Ring-Chain Isomerism of N-(2-Hydroxyalkyl)nitrones, III. Nitrones of 2-Furancarbaldehydes

The ring-chain isomerism of N-(2-hydroxyalkyl)nitrones 3, obtained from 2-furancarbaldehyde and its 5-dialkylamino and 5-nitro derivatives, is studied by acylation of 3 with diphenylborinic acid, carboxylic acids, and isocyanates.Dependent on the kind of

Mechanism of the Reaction of Aldehydes of the Furan Series with Secondary Amines in Methanol

The reaction of 5-halofurfurals with piperidine and morpholine in methanol under various reaction conditions was investigated by means of spectrophotometry.The kinetics of the stepwise addition of the amine to the aldehyde function of the halofurfural were studied in the case of a dilute solution, while the conversion of the aldehyde to a 5-N,N-dialkylaminofurfurylidene-N,N-dialkylimmonium salt, for which two autocatalysis mechanisms were observed, was investigated in the case of a concentrated solution.Reaction intermediates, viz., 5-halofurfurylidene-N,N-bis(dialkylamines), were isolated preparatively and investigated.