228728-81-2

Basic information

• Product Name: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
• Synonyms: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
• CAS NO: 228728-81-2
• Molecular Formula: C12H9F2NO3
• Molecular Weight: 253.203
• Mol File: 228728-81-2.mol

Chemical Properties

• Boiling Point: 344.5°C at 760 mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 6.56E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(228728-81-2)
• EPA Substance Registry System: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(228728-81-2)

Safety Data

• Hazardous Substances Data: 228728-81-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9F2NO3/c1-2-18-12(17)7-5-15-10-6(11(7)16)3-4-8(13)9(10)14/h3-5H,2H2,1H3,(H,15,16)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 4519-40-8 2,3-difluoroanilline 
• 185010-80-4 2-[(2,3-Difluoro-phenylamino)-methylene]-malonic acid diethyl ester 

Downstream Products

• 318685-51-7 Ethyl 4-chloro-7,8-difluoro-quinoline-3-carboxylate 
• 228728-17-4 7,8-difluoro-4-hydroxy-3-quinolinecarboxylic acid 

Relevant articles and documents

Photochemistry of some non zwitterionic fluoroquinolones

Two non zwitterionic analogues of fluoroquinolone drugs, viz. 1-ethyl-7-piperidino-8-fluoroquinol-4- one-3-carboxylic acid and 1-ethyl-7-piperidino-6,8-difluoroquinol-4-one-3-carboxylic acids have been synthesized and their photochemistry has been investigated. Both compound undergo photoheterolysis of the C8 F bond generating a triplet cation that either inserts into the 1-alkyl chain or is trapped or reduced by external nucleophiles. The reaction is analogous to that observed with the corresponding (zwitterionic) 7-piperazino derivatives, but the quantum yield is ca five times lower. This supports the rationalization that in the latter case assistance to defluorination by the N+ H bond has a determining role.

THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES

The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below and can exist in tautomeric forms: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).

Benzo[f]naphthyridine derivatives, their preparation and compositions containing them

Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.

An NMR study of halogenated 1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylates

Ethyl 1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylate and 29 of its mono-, di-and tri-fluoro and/or -chloro derivatives were synthesized and their 1H, 13C and 19F NMR spectra were recorded. 1H, 13C and 19F chemical shifts, JHH, JFH, JCF and JFF coupling constants are reported. The 13C substituent chemical shift values of the chloro and fluoro substituents were calculated by linear multiple regression.