228728-81-2

Basic information

• Product Name: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
• Synonyms: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
• CAS NO: 228728-81-2
• Molecular Formula: C12H9F2NO3
• Molecular Weight: 253.203
• Mol File: 228728-81-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 344.5°C at 760 mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 6.56E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(228728-81-2)
• EPA Substance Registry System: 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester(228728-81-2)

Safety Data

• Hazardous Substances Data: 228728-81-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9F2NO3/c1-2-18-12(17)7-5-15-10-6(11(7)16)3-4-8(13)9(10)14/h3-5H,2H2,1H3,(H,15,16)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 4519-40-8 2,3-difluoroanilline 
• 185010-80-4 2-[(2,3-Difluoro-phenylamino)-methylene]-malonic acid diethyl ester 

Downstream Products

• 318685-51-7 Ethyl 4-chloro-7,8-difluoro-quinoline-3-carboxylate 
• 228728-17-4 7,8-difluoro-4-hydroxy-3-quinolinecarboxylic acid 

Relevant articles and documents

Photochemistry of some non zwitterionic fluoroquinolones

Two non zwitterionic analogues of fluoroquinolone drugs, viz. 1-ethyl-7-piperidino-8-fluoroquinol-4- one-3-carboxylic acid and 1-ethyl-7-piperidino-6,8-difluoroquinol-4-one-3-carboxylic acids have been synthesized and their photochemistry has been investigated. Both compound undergo photoheterolysis of the C8 F bond generating a triplet cation that either inserts into the 1-alkyl chain or is trapped or reduced by external nucleophiles. The reaction is analogous to that observed with the corresponding (zwitterionic) 7-piperazino derivatives, but the quantum yield is ca five times lower. This supports the rationalization that in the latter case assistance to defluorination by the N+ H bond has a determining role.

Benzo[f]naphthyridine derivatives, their preparation and compositions containing them

Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for preparing such compounds; and compositions comprising them.