228730-86-7Relevant academic research and scientific papers
Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
van Oeveren, Arjan,Pio, Barbara A.,Tegley, Christopher M.,Higuchi, Robert I.,Wu, Min,Jones, Todd K.,Marschke, Keith B.,Negro-Vilar, Andres,Zhi, Lin
, p. 1523 - 1526 (2007/10/03)
A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent recep
Switching Androgen Receptor Antagonists to Agonists by Modifying C-Ring Substituents on Piperidinoquinolinone
Zhi, Lin,Tegley, Christopher M.,Marschke, Keith B.,Jones, Todd K.
, p. 1008 - 1012 (2007/10/03)
New nonsteroidal human androgen receptor (hAR) agonists were developed from an hAR antagonist pharmacophore, 2(1H-piperidinoquinolinone. (+/-)-trans-7,8-diethyl-4-trifluoromethyl-2(1H)-piperidinoquinolinone was synthesized and demonstrated p
