22882-43-5Relevant academic research and scientific papers
Multigram synthesis of trans -2-(trifluoromethyl)cyclopropanamine
Bezdudny, Andrii V.,Klukovsky, Denis,Simurova, Natalia,Mykhailiuk, Pavel K.,Shishkin, Oleg V.,Pustovit, Yurii M.
, p. 119 - 122 (2011)
2-(Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch. Georg Thieme Verlag Stuttgart · New York.
Synthesis of trans-(2-aminocyclopropyl)alanine - A key constituent of the novel antitumor antibiotic belactosin A
Brandl,Kozhushkov,Loscha,Kokoreva,Yufit,Howard,De Meijere
, p. 1741 - 1744 (2007/10/03)
Racemic 3-(trans-2-aminocyclopropyl)alanine was prepared in its 3,3-dideuterio-labelled form 3b from tert-butyl 2,3-dibromopropanoate 4 and nitromethane through a nine-step sequence in 8% overall yield. The newly developed access to enantiomerically pure (trans-2-nitrocyclopropyl)methanol (S,S)-6a also constitutes a formal synthesis of enantiomerically pure 3-(trans-2-aminocyclopropyl)alanine (S,S,S)-3a, a key intermediate for the total synthesis of the novel antitumor antibiotic belactosin A.
