22883-28-9Relevant academic research and scientific papers
Discovery of a novel series of indolylchalcone-benzenesulfonamide hybrids acting as selective carbonic anhydrase II inhibitors
Singh, Priti,Purnachander Yadav, Parvatha,Swain, Baijayantimala,Thacker, Pavitra S.,Angeli, Andrea,Supuran, Claudiu T.,Arifuddin, Mohammed
, (2021/02/03)
The primary sulfonamide group is one of the most efficient zinc binding group (ZBG) for designing carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. In the present study primary sulfonamide linked with indolylchalcone were designed. The newly synthesized molecules (5a-r) were examined against four human (h) CA isoforms (hCA I, hCA II, hCA IX and hCA XIII). These sulfonamides showed good inhibition activity against isoforms hCA I, hCA II and hCA XIII. Compound 5i (2.3 nM), 5m (2.4 nM), 5o (3.6 nM) and 5q (7.0 nM) were more potent than standard drug AAZ (12.1 nM) against isoform hCA II, respectively. Most of the other compounds in the present series inhibited hCA XIII and hCA IX in the range of 50 nM ? 100 nM.
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids
Angeli, Andrea,Arifuddin, Mohammed,Purnachander Yadav, P.,Sigalapalli, Dilep Kumar,Singh, Priti,Supuran, Claudiu T.,Swain, Baijayantimala,Thacker, Pavitra S.
, (2020/04/15)
Sulfonamide is one of the most promising classes of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1,2,3-triazole (6a-q) has been synthesized by click chemistry reaction and in
Synthesis, Characterisation, Molecular Docking, Anti-microbial and Anti-diabetic Screening of Substituted 4-indolylphenyl-6-arylpyrimidine-2-imine Derivatives
Ramya, Veerasamy,Vembu, Santhirakasu,Ariharasivakumar, Ganesan,Gopalakrishnan, Manathusamy
, p. 515 - 526 (2017/09/12)
The purpose of the research is to synthesise a novel series of (E)-2-(4-(1H-indol-3-yl)-6-p-substituted phenylpyrimidin-2-yl)dimethylguanidine derivatives since 3-(1H-indol-3-yl)-1-p-substituted phenylprop-2-en-1-one and evaluate their molecular docking s
An efficient method for the synthesis of isoxazolines under microwave irradiation and solvent-free conditions
Patil, Pravin O.,Bari, Sanjay B.
, p. 3588 - 3590 (2013/04/24)
A facile method for the synthesis of new isoxazoline derivatives are being reported starting from substituted 1-(1H-indol-3-yl)-3-(substituted aryl)-prop-1-en-3-ones and hydroxylamine hydrochloride under solvent free conditions and microwave irradiation.
Solvent effect profiles of absorbance and fluorescence spectra of some indole based chalcones
Saroj, Manju Kumari,Sharma, Neera,Rastogi, Ramesh C.
experimental part, p. 2213 - 2227 (2012/06/15)
The photophysical properties of a series of 3-(1' H-Indol-3′-yl)-1- phenylprop-2-en-1-one and its derivatives (indole chalcones) were studied in different solvents. Solvent effects on the absorption and fluorescence spectra were quantified using Reichardt
Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives
Biradar,Sasidhar,Parveen
scheme or table, p. 4074 - 4078 (2010/09/18)
A new series of novel indole derivatives containing barbitone moiety (5a-i) are synthesized by simple and efficient condensation of chalcones (3a-i) with barbituric acid (4). The synthesized compounds are screened for their antioxidant (free radical scave
Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/- 4-morpholin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory agents
Amir, Mohammad,Javed, Sadique Akhtar,Kumar, Harish
scheme or table, p. 299 - 310 (2011/01/12)
The synthesis of new indole derivatives bearing isoxazoline moiety (3a-d and 4a-d) has been described. IR, 1H NMR, and mass spectral data supported the structures of synthesized compounds. The compounds were tested in vivo for their anti-inflam
