228854-68-0

Basic information

• Product Name: propionic acid N'-[4-(6-chloro-2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazide
• CAS NO: 228854-68-0
• Molecular Weight: 349.798
• Mol File: 228854-68-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: propionic acid N'-[4-(6-chloro-2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: propionic acid N'-[4-(6-chloro-2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazide(228854-68-0)
• EPA Substance Registry System: propionic acid N'-[4-(6-chloro-2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazide(228854-68-0)

Safety Data

• Hazardous Substances Data: 228854-68-0(Hazardous Substances Data)

Upstream product

• 20953-13-3 1-propanoyl-3-thiosemicarbazide 
• 106577-99-5 3-(2-bromoacetyl)-6-chloro-2H-chromen-2-one 
• 53653-66-0 3-acetyl-6-chlorocoumarin 

Relevant articles and documents

Condensation of 3-methyl/ethyl-5-mercapto-s-triazole with 3- acetylcoumarin and its derivatives

3-Methyl/ethyl-5-mercapto-s-triazoles 2 on condensation with either 3- (2-bromoacetyl)coumarins or with substituted 3-acetyl comarins using bromine in the presence of trichloro-(N,N'-ethylene-bis-aminobenzamide) lanthanum and samarium as a catalyst, followed by cyclization of the intermediate 3-alkyl- 5-coumarinacyl-thio-s-triazole 3 using PPA furnish 3-alkyl-5- coumarinylthiazolo[3,2-b]-s-triazoles 4 and not the isomeric 3-alkyl-5- coumarinylthiazolo[2.3-c]-s-triazoles 6. 2-Acetyl- or 2-propanoylhydrazino- 4-coumarinyl-thlazolo hydrobromides 5 obtained from the reaction of acetyl/propanoyl thiosemicarbazides 1 with either substituted 3-(2- bromoacetyl) coumarins or with bromine and substituted 3-acetylcoumarin using trichloro-(N,N'-ethylene-bis-aminobenzamide)lanthanum (III) and samarium (III) as a catalyst, on treatment with phosphoryl chloride undergo facile cyclization yielding 5-alkyl-5-coumarinylthiazolo[2.3-c]-s-triazole 6.