22888-56-8 Usage
General Description
3-Nitro-DL-Phenylalanine is a chemical compound that is used in scientific research, more specifically in biochemistry and molecular biology. It belongs to the category of organic compounds known as phenylalanine and derivatives, which contain phenylalanine or a derivative thereof, obtained by reaction derivatives thereof at the amino group or carboxy group, or from the reaction of phenylalanine or its derivatives with an alcohol, an acid, or a derivative of the latter. This particular compound contains both levo (L) and dextro (D) isomers. It has a role as a metabolite and bears a formula of C9H10N2O4. It can be harmful and may cause skin and eye irritation, allergic skin reaction, or cause respiratory irritation if inhaled.
Check Digit Verification of cas no
The CAS Registry Mumber 22888-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,8,8 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 22888-56:
(7*2)+(6*2)+(5*8)+(4*8)+(3*8)+(2*5)+(1*6)=138
138 % 10 = 8
So 22888-56-8 is a valid CAS Registry Number.
22888-56-8Relevant articles and documents
Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines
Weise, Nicholas J.,Thapa, Prasansa,Ahmed, Syed T.,Heath, Rachel S.,Parmeggiani, Fabio,Turner, Nicholas J.,Flitsch, Sabine L.
, p. 995 - 998 (2020/01/21)
The conversion of carboxylic acids, such as acrylic acids, to amines is a transformation that remains challenging in synthetic organic chemistry. Despite the ubiquity of similar moieties in natural metabolic pathways, biocatalytic routes seem to have been overlooked for this purpose. Herein we present the conception and optimisation of a two-enzyme system, allowing the synthesis of β-phenylethylamine derivatives from readily-available ring-substituted cinnamic acids. After characterisation of both parts of the reaction in a two-step approach, a set of conditions allowing the one-pot biotransformation was optimised. This combination of a reversible deaminating and irreversible decarboxylating enzyme, both specific for the amino acid intermediate in tandem, represents a general method by which new strategies for the conversion of carboxylic acids to amines could be designed.
