22890-19-3Relevant academic research and scientific papers
Sulfoglycolipid antigens, their process of preparation, and their use against tuberculosis
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, (2008/12/07)
The present invention relates to compounds of the following general formula: their process of preparation and their use in the treatment or the prophylaxis of tuberculosis.
Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: Possible intermediates in the biosynthesis of mycolic acids in mycobacteria
Besra, Gurdyal S.,Minnikin, David E.,Wheeler, Paul R.,Ratledge, Colin
, p. 23 - 34 (2007/10/02)
The high molecular weight 2-alkyl-3-hydroxy mycolic acids are key structural components of the cell envelope of pathogenic mycobacteria, such as Mycobacterium tuberculosis. A prime target for drug action would be the initial stages where the biosynthetic pathways diverge from those of ordinary fatty acids. It has been postulated that the pathway for the α-mycolates, without oxygen functions in addition to the hydroxy-acid unit, appears to diverge from (Z)-tetracos-5-enoic acid. The biosynthesis of oxygenated mycolic acids is considered to possibly diverge from (E)-6-(R)-methyltetracos-4-enoic and (E)-6-(S)-methyltetracos-4-enoic acids. This communication describes the synthesis of esters of these acids in order to test their potential role in the biosynthesis of mycolic acids.
