22896-78-2Relevant articles and documents
Organocatalytic Enantioselective Aminoalkylation of 5-Aminopyrazole Derivatives with Cyclic Imines
Carceller-Ferrer, Laura,González del Campo, Aleix,Vila, Carlos,Blay, Gonzalo,Mu?oz, M. Carmen,Pedro, José R.
, p. 7450 - 7454 (2020)
In this communication, an efficient asymmetric aminoalkylation of 5-aminopyrazole derivatives with cyclic benzoxathiazine 2,2-dioxides catalyzed by a quinine-derived squaramide in dichloromethane has been established. This is the first example of 5-aminopyrazole derivatives in asymmetric catalysis. A variety of chiral sulfamidates bearing an aminopyrazole moiety were obtained in good yields (up to 98 %) and moderate to excellent enantioselectivities (up to 99 %ee).