22900-83-0

Basic information

• Product Name: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOX&;Ethyl 2-bromop4-methyl-1,3-thiazole-5-carboxylate;2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate 97%;2-Bromo-4-methyl-5-thiazolecarboxylic acid ethyl ester
• CAS NO: 22900-83-0
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11
• Product Categories: Thiazole series;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiazoles;ThiazolesHeterocyclic Building Blocks;thiazole, carboxylate
• Mol File: 22900-83-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 65-69 °C(lit.)
• Boiling Point: 287.086 °C at 760 mmHg
• Flash Point: 127.426 °C
• Appearance: /
• Density: 1.573 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.10±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(22900-83-0)
• EPA Substance Registry System: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(22900-83-0)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36
• RIDADR: 1759
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 22900-83-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

It finds its application in the preparation of thiazole-4- and -5-carboxylates, and an infrared study of their rotational isomers and in the discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.

InChI:InChI=1/C7H8BrNO2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3

Upstream product

• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 110-46-3 isopentyl nitrite 
• 84911-18-2 ethyl 2-bromoacetoacetate 
• 141-97-9 ethyl acetoacetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 78633-83-7 2-(p-Acetylaminobenzenesulfonamido)-4-methyl-5-carboethoxythiazole 
• 40003-41-6 2-bromo-4-methyl-thiazole-5-carboxylic acid 
• 40003-13-2 2-(4-chloro-3-methyl-phenoxy)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 53040-04-3 2-(4-methoxycarbonylmethoxy-phenylsulfanyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-97-0 2-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-99-2 2-[4-(2-methoxycarbonyl-ethoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58535-98-1 2-[4-(1-methoxycarbonyl-ethoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58536-01-9 2-[4-(3-methoxycarbonyl-propoxy)-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-24-5 4-methyl-2-(toluene-4-sulfonyl)-thiazole-5-carboxylic acid ethyl ester 
• 40003-26-7 2-(4-chloro-benzenesulfonyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-23-4 2-benzenesulfonyl-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-25-6 2-(4-acetylamino-benzenesulfonyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 58536-00-8 2-[4-(2-methoxycarbonyl-ethoxy)-3-methyl-phenylsulfanyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 40003-15-4 ethyl 4-methyl-2-phenylsulfanylthiazole-5-carboxylate 

Relevant articles and documents

Green synthesis approaches of 2-bromo-4-methyl thiazole-5-carboxamide derivatives as potent microbial agents

As a part of our ongoing research in the development of new, selective and environmental friendly methodologies, herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400 (PEG-400) as a solvent. All

Facile synthesis of novel (1-Aryl/alkyl-1H-1,2,3-triazol- 4-yl)methyl-2-bromo-4-methylthiazole-5-carboxylates by Cu(I) catalyzed click reaction

A number of novel thiazole-triazole heterocycles bearing (1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl- 2-bromo-4-methylthiazole-5-carboxylates was synthesized through the click reaction. The structure of all new synthesized compounds was established by sup

Synthesis and Fungicidal Activity of Novel 2-Heteroatomthiazole-based Carboxanilides

A new series of 2-heteroatomthiazole-based carboxanilides (8) are prepared by reacting 2-heteroatomthiazole-based carboxylic acid chlorides with 2,6-dibromo-4-(trifluoromethoxy)aniline. The structures of all the newly synthesized compounds were supported by spectroscopic data NMR, MS, and elemental analysis, etc. Bioassay showed that the compounds exhibited potent fungicidal activities against Rhizoctonia solani, etc. Particularly, N-(2,6-dibromo-4-(trifluoromethoxy)phenyl)-2-methoxy-4-(trifluoromethyl)thiazole-5-carboxamide (8a-2) showed fungicidal potency which was comparable to that of Thifluzamide, the only commercialized thiazole carboxanilide fungicides of succinate dehydrogenase inhibitor (SDHI).