22900-83-0 Usage
Description
Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate is a white powder chemical compound that belongs to the thiazole family. It is characterized by its unique chemical structure, which includes a thiazole ring with a bromine atom at the 2nd position, a methyl group at the 4th position, and a carboxylate group attached to the 5th position through an ester linkage with ethyl.
Uses
Used in Pharmaceutical Industry:
Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate is used as a key intermediate in the synthesis of various thiazole-4and -5-carboxylates. These compounds have potential applications in the development of new pharmaceuticals due to their diverse chemical properties and reactivity.
Used in Chemical Research:
Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate is also utilized in chemical research, particularly in the study of rotational isomers of thiazole-4and -5-carboxylates. The research on these isomers can provide valuable insights into the structural and conformational aspects of these compounds, which can be useful for designing new molecules with specific properties and applications.
Used in Drug Discovery:
Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate has been identified as a component in the discovery of thiazolylpyridinone SCD1 inhibitors. These inhibitors are designed to have preferential liver distribution, which can help in targeting liver-related diseases more effectively. Additionally, these inhibitors are aimed at reducing mechanism-based adverse effects, making them potentially safer and more effective therapeutic options.
Check Digit Verification of cas no
The CAS Registry Mumber 22900-83-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,9,0 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22900-83:
(7*2)+(6*2)+(5*9)+(4*0)+(3*0)+(2*8)+(1*3)=90
90 % 10 = 0
So 22900-83-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BrNO2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3
22900-83-0Relevant articles and documents
Green synthesis approaches of 2-bromo-4-methyl thiazole-5-carboxamide derivatives as potent microbial agents
Miryala, Jeevanreddy,Morthad, Mahesh,Battu, Satyanarayana
, p. 297 - 302 (2019)
As a part of our ongoing research in the development of new, selective and environmental friendly methodologies, herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400 (PEG-400) as a solvent. All
Facile synthesis of novel (1-Aryl/alkyl-1H-1,2,3-triazol- 4-yl)methyl-2-bromo-4-methylthiazole-5-carboxylates by Cu(I) catalyzed click reaction
Sudhakar,Thirupathi,Balakishan,Narsima chary,Ravi
, p. 1722 - 1729 (2016)
A number of novel thiazole-triazole heterocycles bearing (1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl- 2-bromo-4-methylthiazole-5-carboxylates was synthesized through the click reaction. The structure of all new synthesized compounds was established by sup
Synthesis and Fungicidal Activity of Novel 2-Heteroatomthiazole-based Carboxanilides
Liu, Aiping,Wang, Xiaoguang,Liu, Xingping,Li, Jianming,Chen, Haobin,Hu, Li,Yu, Wanqi,He, Lian,Liu, Weidong,Huang, Mingzhi
, p. 1625 - 1629 (2017/03/27)
A new series of 2-heteroatomthiazole-based carboxanilides (8) are prepared by reacting 2-heteroatomthiazole-based carboxylic acid chlorides with 2,6-dibromo-4-(trifluoromethoxy)aniline. The structures of all the newly synthesized compounds were supported by spectroscopic data NMR, MS, and elemental analysis, etc. Bioassay showed that the compounds exhibited potent fungicidal activities against Rhizoctonia solani, etc. Particularly, N-(2,6-dibromo-4-(trifluoromethoxy)phenyl)-2-methoxy-4-(trifluoromethyl)thiazole-5-carboxamide (8a-2) showed fungicidal potency which was comparable to that of Thifluzamide, the only commercialized thiazole carboxanilide fungicides of succinate dehydrogenase inhibitor (SDHI).
