229007-60-7Relevant academic research and scientific papers
Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma
Lagu, Bharat,Gerchak, Chrissy,Pan, Meng,Hou, Cuifen,Singer, Monica,Malaviya, Ravi,Matheis, Michele,Olini, Gil,Cavender, Druie,Wachter, Michael
, p. 4382 - 4386 (2008/02/09)
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characte
Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety
Shiraishi, Mitsuru,Aramaki, Yoshio,Seto, Masaki,Imoto, Hiroshi,Nishikawa, Youichi,Kanzaki, Naoyuki,Okamoto, Mika,Sawada, Hidekazu,Nishimura, Osamu,Baba, Masanori,Fujino, Masahiko
, p. 2049 - 2063 (2007/10/03)
The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [125I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium m
