229007-97-0

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 14643-62-0 tris(p-methylphenyl) borate 
• 62157-62-4 3-(5'-bromothiophen-2'-yl)-(E)-propenoic acid methyl ester 

Downstream Products

• 229005-41-8 (E)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-3-[5-(4-methylphenyl)thiophen-2-yl]-acrylic amide 
• 1026010-24-1 3-(5-p-tolyl-thiophen-2-yl)-acryloyl chloride 

Relevant academic research and scientific papers

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.