229009-42-1 Usage
General Description
4-(1-piperidinyl)phenylboronic acid hydrochloride, also known as 4-piperidinylphenylboronic acid hydrochloride, is a chemical compound with potential applications in medicinal chemistry and drug synthesis. It is a boronic acid derivative containing a piperidine ring, which makes it a valuable building block for the construction of complex organic molecules. 4-(1-PIPERIDINYL)PHENYLBORONIC ACID HCL is widely used in the development of pharmaceuticals, particularly in the synthesis of molecules with potential therapeutic properties such as anticancer, antiviral, and antibacterial agents. Its unique structure and reactivity make it a valuable tool for chemical research and drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 229009-42-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,9,0,0 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 229009-42:
(8*2)+(7*2)+(6*9)+(5*0)+(4*0)+(3*9)+(2*4)+(1*2)=121
121 % 10 = 1
So 229009-42-1 is a valid CAS Registry Number.
229009-42-1Relevant articles and documents
Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors
Park, Byung Sun,El-deeb, Ibrahim M.,Yoo, Kyung Ho,Han, Dong Keun,Tae, Jin Sung,Lee, So Ha
, p. 3629 - 3634 (2013/01/16)
A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.
