229153-49-5Relevant articles and documents
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: A new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite
Portevin,Tordjman,Pastoureau,Bonnet,De Nanteuil
, p. 4582 - 4593 (2000)
Novel tetrahydro-2H-isoindoles have been prepared and evaluated as inhibitors of the COX-2 isoenzyme. A 1,3-diaryl substitution on the central polycyclic ring system and absence of a sulfonyl moiety are the two structural features of this chemical series.
Pyrrole compounds
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, (2008/06/13)
Compounds of formula (I): STR1 wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C1 -C6)-acyl, R1 and R2, which may be identical or different, each represents independently of the other aryl, heteroaryl, or (C5 -C7)-cycloalkyl, or one of those groups optionally substituted, A, together with the atoms in common with the pyrrole, represents saturated or unsaturated, monocyclic or bicyclic (C3 -C12)-cycloalkyl, or a saturated heterocycle having 5 to 7 ring members and containing one or two nitrogen, or 7-oxabicyclo[2.2.1]heptane, or one of those groups optionally substituted, their isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, pharmaceutical compositions thereof, and use thereof as medicaments.
