22919-50-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4(1H,3H)-Pyrimidinedione, 1-(3-bromopropyl)-5-methylis used as a building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of new compounds with potential therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2,4(1H,3H)-Pyrimidinedione, 1-(3-bromopropyl)-5-methylis utilized in the development of new agrochemicals, such as pesticides and herbicides. Its versatility enables the design of novel compounds with improved efficacy and selectivity.
Used in Organic Compound Synthesis:
2,4(1H,3H)-Pyrimidinedione, 1-(3-bromopropyl)-5-methylis employed as a key intermediate in the synthesis of various heterocyclic compounds. Its presence in these compounds can impart unique chemical and biological properties, making it valuable in the field of organic chemistry.
Used in Research and Development:
This chemical compound is also used in research and development processes, where it can be employed to explore new chemical reactions, investigate its reactivity, and study its potential applications in various fields, including material science and nanotechnology.

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 65-71-4 thymin 

Downstream Products

• 22917-75-5 1,1'-trimethylenebis(thymine) 
• 125013-61-8 7-Methyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]oxazin-8-one 
• 22917-84-6 9-<3-(thym-1-yl)propyl>adenine 
• 81644-56-6 6-deoxy-6-<(3-thym-1-yl)propyl)thio>-β-cyclodextrin 
• 84691-71-4 9-<3-(thym-1-yl)propyl>-6-diphenylmethylthiopurine 
• 78497-51-5 5-Methyl-1-[3-(7-oxo-7H-furo[3,2-g]chromen-9-yloxy)-propyl]-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Lignin Nanoparticles Deliver Novel Thymine Biomimetic Photo-Adducts with Antimelanoma Activity

We report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane spacer between nucleobases and characterized by antimelanoma activity against two mutated cancer cell lines overexpressing human Topoisomerase 1 (TOP1), namely SKMEL28 and RPMI7951. Among them, Dewar Valence photo-adducts showed a selectivity index higher than the corresponding pyrimidine-(6-4)-pyrimidone and cyclobutane counterpart and were characterized by the highest affinity towards TOP1/DNA complex as evaluated by molecular docking analysis. The antimelanoma activity of novel photo-adducts was retained after loading into UV photo-protective lignin nanoparticles as stabilizing agent and efficient drug delivery system. Overall, these results support a combined antimelanoma and UV sunscreen strategy involving the use of photo-protective lignin nanoparticles for the controlled release of thymine dimers on the skin followed by their sacrificial transformation into photo-adducts and successive inhibition of melanoma and alert of cellular UV machinery repair pathways.

NMR and UV Study of 1,1′-(α,ω-Alkanediyl)bis[thymine] and l,1′-(α,ω-Alkanediyl)bis[uracil]

Treatment of thymine or uracil with Br(CH2)nBr (n = 3-10) in the presence of t-BuOK gave 1,1′-(α,ω-alkanediyl)bis[thymine] or 1,1′-(α,ω-alkanediyl)bis[uracil] together with l-(ω-bromoalkyl)thymine or l-(ω-bromoalkyl)uracil. The structures of these products were determined on the basis of the coupling constants between 5- and 3-positions of uracil ring on the 1H NMR spectra. Molecular aggregation of the thymine and uracil rings of these compounds in aqueous solution was studied on the basis of their 1H NMR and UV spectra. A stacking interaction of the two thymine rings linked by shorter polymethylene chains such as trimethylene and tetramenthylene groups was observed.