22928-93-4

Basic information

• Product Name: 4-methyl-[1,2]diazepine-1-carboxylic acid ethyl ester
• CAS NO: 22928-93-4
• Molecular Weight: 180.206
• Mol File: 22928-93-4.mol

Chemical Properties

• CAS DataBase Reference: 4-methyl-[1,2]diazepine-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-[1,2]diazepine-1-carboxylic acid ethyl ester(22928-93-4)
• EPA Substance Registry System: 4-methyl-[1,2]diazepine-1-carboxylic acid ethyl ester(22928-93-4)

Safety Data

• Hazardous Substances Data: 22928-93-4(Hazardous Substances Data)

Upstream product

• 22928-86-5 1-ethoxycarbonylimino-3-methyl-pyridinium ylide 

Downstream Products

• 75660-77-4 2-ethoxycarbonyl-6-methyl-2H-2,4-diazabicyclo<3.2.0>hepta-3,6-diene 
• 41322-67-2 (5-methyl-pyridin-2-yl)-carbamic acid ethyl ester 
• 40927-68-2 2-Carbethoxy-5-methyl-2,3-diazabicyclo<3.2.0>hepta-3,6-dien 
• 75633-16-8 1-ethoxycarbonyl-5-methyl-1H-1,3-diazepine 

Relevant articles and documents

1,3-Cycloaddition of benzonitrile oxides to diazepines.II. 1-Ethoxycarbonyl-4-methyl- and 6-methyl-1,2-diazepine

Stable arylnitrile oxides (1b-e) and 1-ethoxycarbonyl-4-methyl and 6-methyl-1,2-diazepines (2f and 2h) undergo 1,3-cycloaddition reactions to give 1,2,4-oxadiazole derivatives (3) as the most abundant products. Secondary products of the class of isoxazoles (5 or 8) and 4,5-dihydroisoxazoles (6 or 7) were also identified. Overall kinetics were measured at 70.0°C, in mixtures of 1,1,2,2-tetrachloroethane and DMF; rate coefficients for the parallel reactions were obtained. Substituent and solvent effects are discussed.